Characterization of neuroblastic tumors using 18F-FDOPA PET

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Title:	Characterization of neuroblastic tumors using 18F-FDOPA PET
Authors:	吳沛翊;Lu, Meng-Yao;Liu, Yen-Lin;Chang, Hsiu-Hao;Jou, Shiann-Tarng;Yang, Yung-Li;Lin, Kai-Hsin;Lin, Dong-Tsamn;Lee, Ya-Ling;Lee, Hsinyu;Wu, Pei-Yi;Luo, Tsai-Yueh;Shen, Lie-Hang;Huang, Shiu-Feng;Liao, Yung-Feng;Hsu, Wen-Ming;Tzen, Kai-Yuan
Contributors:	生醫理工學院生命科學系
Keywords:	3-Iodobenzylguanidine;Biological Transport;Carboxy-Lyases - genetics;Catecholamines - metabolism;Dihydroxyphenylalanine - analogs & derivatives;Dihydroxyphenylalanine - metabolism;Female;Fluorodeoxyglucose F18;Gene Expression Regulation, Neoplastic;Humans;Infant;Male;Neuroblastoma - diagnostic imaging;Neuroblastoma - genetics;Neuroblastoma - metabolism;Neuroblastoma - pathology;Positron-Emission Tomography;Retrospective Studies;Sensitivity and Specificity;Vanilmandelic Acid - urine
Date:	2013-01-01
Issue Date:	2026-04-23 11:11:58 (UTC+8)
Publisher:	Society of Nuclear Medicine and Molecular Imaging;United States
Abstract:	摘要： Neuroblastic tumors are childhood neoplasms that possess amino acid decarboxylase (AADC) activity and can theoretically be imaged by (18)F-fluorodihydroxyphenylalanine ((18)F-FDOPA) PET, a new diagnostic tool for neuroendocrine tumors. In this study, we explored the accuracy and clinical role of (18)F-FDOPA PET in neuroblastic tumors. From 2008 to 2011, patients with tissue-proven neuroblastic tumors receiving (18)F-FDOPA PET at initial diagnosis or during follow-ups were enrolled. The sensitivity and specificity of (18)F-FDOPA PET were compared with those of (123)I-metaiodobenzylguanidine ((123)I-MIBG) scintigraphy and (18)F-FDG PET, using tumor histology as the standard. The maximum standardized uptake value and tumor-to-liver uptake ratio on (18)F-FDOPA PET were measured and correlated with AADC messenger RNA level in tumor tissue. Fifty tumors from 34 patients, including 42 neuroblastic tumors and 8 lesions without viable tumor cells, were eligible for analysis. (18)F-FDOPA PET successfully detected neuroblastic tumors of different histologic types in various anatomic sites, at a sensitivity of 97.6% (87.4%-99.9%) and a specificity of 87.5% (47.3%-99.7%). In tumors with concomitant studies, (18)F-FDOPA PET demonstrated a higher sensitivity than (123)I-MIBG scintigraphy (n = 18; P = 0.0455) or (18)F-FDG PET (n = 46; P = 0.0455). Among the 18 tumors with concomitant (123)I-MIBG scans, 4 tumors with viable cells were (123)I-MIBG-negative but were successfully detected by (18)F-FDOPA PET. The tumor uptake of (18)F-FDOPA significantly correlated with AADC expression (n = 15 nonhepatic tumors; maximum standardized uptake value, P = 0.0002; tumor-to-liver uptake ratio, P < 0.0001). (18)F-FDOPA PET showed high sensitivity and specificity in detecting and tracking neuroblastic tumors in this preliminary study with a small cohort of patients and might be complementary to (123)I-MIBG scintigraphy and (18)F-FDG PET. By correlating with AADC expression, (18)F-FDOPA PET might serve as a useful imaging tool for the functional assessment of neuroblastic tumors. 其他題名： J Nucl Med 出版者： United States 出版日期： 2013-01 出處： Journal of Nuclear Medicine, 2013-01, Vol.54 (1), p.42-49 識別號： ISSN: 0161-5505 識別號： ISSN: 1535-5667 識別號： ISSN: 2159-662X 識別號： EISSN: 2159-662X 識別號： EISSN: 1535-5667 識別號： DOI: 10.2967/jnumed.112.102772 識別號： PMID: 23213196
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