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| 題名: | Chicken Embryos as a Potential New Model for Early Onset Type i Diabetes |
| 作者: | 黃佳瑜;Ko, Gladys Y.-P.;Hong, Min-Pyo;Park, So-Young;Huang, Cathy Chia-Yu;Ko, Michael L.;Shi, Liheng;Wu, Chaodong |
| 貢獻者: | 生醫理工學院生命科學系 |
| 關鍵詞: | Analysis;Animals;Apoptosis;Blood Glucose - metabolism;Calcium Channels, L-Type - metabolism;Cataract - blood;Cataract - chemically induced;Cataract - embryology;Chick Embryo;Color Vision;Development and progression;Diabetes;Diabetes Mellitus, Experimental - blood;Diabetes Mellitus, Experimental - chemically induced;Diabetes Mellitus, Experimental - embryology;Diabetes Mellitus, Type 1 - blood;Diabetes Mellitus, Type 1 - chemically induced;Diabetes Mellitus, Type 1 - embryology;Diabetic retinopathy;Diabetic Retinopathy - blood;Diabetic Retinopathy - chemically induced;Diabetic Retinopathy - embryology;Diabetic Retinopathy - physiopathology;Eggs;Embryo Culture Techniques;Embryonic development;Embryos;Glucose;Glucose Transporter Type 4 - metabolism;Insulin;Insulin - blood;Kinases;Medical research;Phosphorylation;Photoreceptors;Poultry;Prediabetic State - blood;Prediabetic State - chemically induced;Prediabetic State - embryology;Proto-Oncogene Proteins c-akt - metabolism;Retina;Retinal Cone Photoreceptor Cells - metabolism;Retinal Cone Photoreceptor Cells - pathology;Rodents;Streptozocin;Time Factors |
| 日期: | 2014-01-01 |
| 上傳時間: | 2026-04-23 11:12:06 (UTC+8) |
| 出版者: | Hindawi Limited;Cairo, Egypt: Hindawi Publishing Corporation |
| 摘要: | 摘要： Diabetic retinopathy (DR) is the leading cause of blindness among the American working population. The purpose of this study is to establish a new diabetic animal model using a cone-dominant avian species to address the distorted color vision and altered cone pathway responses in prediabetic and early diabetic patients. Chicken embryos were injected with either streptozotocin (STZ), high concentration of glucose (high-glucose), or vehicle at embryonic day 11. Cataracts occurred in varying degrees in both STZ- and high glucose-induced diabetic chick embryos at E18. Streptozotocin-diabetic chicken embryos had decreased levels of blood insulin, glucose transporter 4 (Glut4), and phosphorylated protein kinase B (pAKT). In STZ-injected E20 embryos, the ERG amplitudes of both a- and b-waves were significantly decreased, the implicit time of the a-wave was delayed, while that of the b-wave was significantly increased. Photoreceptors cultured from STZ-injected E18 embryos had a significant decrease in L-type voltage-gated calcium channel (L-VGCC) currents, which was reflected in the decreased level of L-VGCCα1D subunit in the STZ-diabetic retinas. Through these independent lines of evidence, STZ-injection was able to induce pathological conditions in the chicken embryonic retina, and it is promising to use chickens as a potential new animal model for type I diabetes.
其他題名： J Diabetes Res
出版者： Cairo, Egypt: Hindawi Publishing Corporation
出版日期： 2014-01-01
出處： Journal of Diabetes Research, 2014-01, Vol.2014 (2014), p.1-10
資源來源： Healthcare Administration Database
版權： Copyright © 2014 Liheng Shi et al.
版權： COPYRIGHT 2014 John Wiley & Sons, Inc.
版權： COPYRIGHT 2014 Hindawi Limited
版權： Copyright © 2014 Liheng Shi et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
版權： Copyright © 2014 Liheng Shi et al. 2014
識別號： ISSN: 2314-6745
識別號： ISSN: 2314-6753
識別號： EISSN: 2314-6753
識別號： DOI: 10.1155/2014/354094
識別號： PMID: 25133191 |
| 顯示於類別: | [生命科學系] 期刊論文
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