Correlation between serum levels of anti-endothelial cell autoantigen and anti-dengue virus nonstructural protein 1 antibodies in dengue patients

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Title:	Correlation between serum levels of anti-endothelial cell autoantigen and anti-dengue virus nonstructural protein 1 antibodies in dengue patients
Authors:	羅月霞;Cheng, Hsien-Jen;Luo, Yueh-Hsia;Wan, Shu-Wen;Lin, Chiou-Feng;Wang, Shan-Tair;Hung, Nguyen Thanh;Liu, Ching-Chuan;Ho, Tzong-Shiann;Liu, Hsiao-Sheng;Yeh, Trai-Ming;Lin, Yee-Shin
Contributors:	生醫理工學院生命科學系
Keywords:	Antibodies, Viral - blood;Autoantigens - blood;Cross Reactions;Dengue Virus - immunology;Endothelial Cells - immunology;Epitopes - immunology;Humans;Severe Dengue - immunology;Severe Dengue - virology;Viral Nonstructural Proteins - immunology
Date:	2015-01-01
Issue Date:	2026-04-23 11:12:11 (UTC+8)
Publisher:	American Society of Tropical Medicine and Hygiene;United States: The American Society of Tropical Medicine and Hygiene
Abstract:	摘要： We have previously shown that anti–dengue virus nonstructural protein 1 (anti-DENV NS1) antibodies cross-react with endothelial cells, and several autoantigens have been identified. This study shows that the antibody levels against these self-proteins are higher in sera from patients with dengue hemorrhagic fever (DHF) than those in control sera. Anti–protein disulfide isomerase (PDI) and anti–heat shock protein 60 (anti-HSP60) IgM levels correlated with both anti–endothelial cells and anti-DENV NS1 IgM titers. A cross-reactive epitope on the NS1 amino acid residues 311–330 (P311–330) had been predicted. We further found that there were higher IgM and IgG levels against P311–330 in DHF patients' sera than those in the control sera. In addition, correlations were observed between anti-PDI with anti-P311–330 IgM and IgG levels, respectively. Therefore, our results indicate that DENV NS1 P311–330 is a major epitope for cross-reactive antibodies to PDI on the endothelial cell surface, which may play an important role in DENV infection–induced autoimmunity. 其他題名： Am J Trop Med Hyg 出版者： United States: The American Society of Tropical Medicine and Hygiene 出版日期： 2015-05-01 出處： The American journal of tropical medicine and hygiene, 2015-05, Vol.92 (5), p.989-995 版權： The American Society of Tropical Medicine and Hygiene. 版權： The American Society of Tropical Medicine and Hygiene 2015 識別號： ISSN: 0002-9637 識別號： ISSN: 1476-1645 識別號： EISSN: 1476-1645 識別號： DOI: 10.4269/ajtmh.14-0162 識別號： PMID: 25758647
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