Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B

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Title:	Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B
Authors:	王陸海;Lin, Kai-Ti;Yeh, Yu-Ming;Chuang, Chi-Mu;Yang, Scarlett Y.;Chang, Jer-Wei;Sun, Shu-Pin;Wang, Yi-Shiang;Chao, Kuan-Chong;Wang, Lu-Hai
Contributors:	生醫理工學院生命科學系
Keywords:	13/51;13/95;14/19;38/32;59/5;631/337/384/331;64/60;692/699/67/1059/99;692/699/67/1517/1709;692/699/67/322;82/29;Animals;Blotting, Western;Cell Line, Tumor;Cell Movement - drug effects;Chromatin Immunoprecipitation;Female;Fluorescent Antibody Technique;Gene Expression Regulation, Neoplastic - drug effects;Gene Expression Regulation, Neoplastic - genetics;Glucocorticoids - metabolism;Glucocorticoids - pharmacology;Heterografts - metabolism;Humanities and Social Sciences;Humans;Hypersensitivity;In Situ Hybridization;Luciferases;Mice;MicroRNAs - genetics;MicroRNAs - metabolism;multidisciplinary;Neoplasm Invasiveness - prevention & control;Neoplasm Metastasis - prevention & control;Ovarian cancer;Ovarian Neoplasms - genetics;Ovarian Neoplasms - metabolism;rap GTP-Binding Proteins - metabolism;Real-Time Polymerase Chain Reaction;Science;Science (multidisciplinary)
Date:	2015-01-08
Issue Date:	2026-04-23 11:12:54 (UTC+8)
Publisher:	Nature Publishing Group;London: Nature Publishing Group UK
Abstract:	摘要： Glucocorticoids are widely used in conjunction with chemotherapy for ovarian cancer to prevent hypersensitivity reactions. Here we reveal a novel role for glucocorticoids in the inhibition of ovarian cancer metastasis. Glucocorticoid treatments induce the expression of miR-708, leading to the suppression of Rap1B, which result in the reduction of integrin-mediated focal adhesion formation, inhibition of ovarian cancer cell migration/invasion and impaired abdominal metastasis in an orthotopic xenograft mouse model. Restoring Rap1B expression reverts glucocorticoid-miR-708 cascade-mediated suppression of ovarian cancer cell invasion and metastasis. Clinically, low miR-708 and high Rap1B are found in late-state ovarian tumours, as compared with normal, and patients with high miR-708 show significantly better survival. Overall, our findings reveal an opportunity for glucocorticoids and their downstream mediators, miR-708 or Rap1B, as therapeutic modalities against metastatic ovarian epithelial cancer. Glucocorticoids show promise for the treatment of ovarian cancer. Here the authors show that glucocorticoids transcriptionally induce the tumour suppressor miR-708, which is downregulated in ovarian cancer, especially in late stages and metastatic tumours. 其他題名： Nat Commun 出版者： London: Nature Publishing Group UK 出版日期： 2015-01-08 出處： Nature communications, 2015-01, Vol.6 (1), p.5917, Article 5917 資源來源： SpringerLink Journals Open Access 版權： The Author(s) 2015 版權： Copyright Nature Publishing Group Jan 2015 版權： Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 識別號： ISSN: 2041-1723 識別號： EISSN: 2041-1723 識別號： DOI: 10.1038/ncomms6917 識別號： PMID: 25569036
Appears in Collections:	[Department of Life Science] journal & Dissertation

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