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https://ir.lib.ncu.edu.tw/handle/987654321/102574
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| 題名: | Improving pharmaceutical protein production in Oryza sativa |
| 作者: | 陸重安;Kuo, Yu-Chieh;Tan, Chia-Chun;Ku, Jung-Ting;Hsu, Wei-Cho;Su, Sung-Chieh;Lu, Chung-An;Huang, Li-Fen |
| 貢獻者: | 生醫理工學院生命科學系 |
| 關鍵詞: | Biotechnology - methods;Gene Expression;Humans;Oryza - metabolism;Plants, Genetically Modified;Recombinant Proteins - biosynthesis;Recombinant Proteins - therapeutic use;Review |
| 日期: | 2013-01-01 |
| 上傳時間: | 2026-04-23 11:13:05 (UTC+8) |
| 出版者: | MDPI Multidisciplinary Digital Publishing Institute;Switzerland: MDPI AG |
| 摘要: | 摘要： Application of plant expression systems in the production of recombinant proteins has several advantages, such as low maintenance cost, absence of human pathogens, and possession of complex post-translational glycosylation capabilities. Plants have been successfully used to produce recombinant cytokines, vaccines, antibodies, and other proteins, and rice (Oryza sativa) is a potential plant used as recombinant protein expression system. After successful transformation, transgenic rice cells can be either regenerated into whole plants or grown as cell cultures that can be upscaled into bioreactors. This review summarizes recent advances in the production of different recombinant protein produced in rice and describes their production methods as well as methods to improve protein yield and quality. Glycosylation and its impact in plant development and protein production are discussed, and several methods of improving yield and quality that have not been incorporated in rice expression systems are also proposed. Finally, different bioreactor options are explored and their advantages are analyzed.
其他題名： Int J Mol Sci
出版者： Switzerland: MDPI AG
出版日期： 2013-04-24
出處： International journal of molecular sciences, 2013, Vol.14 (5), p.8719-8739
資源來源： Publicly Available Content Database
版權： Copyright MDPI AG 2013
版權： 2013 by the authors; licensee MDPI, Basel, Switzerland 2013
識別號： ISSN: 1422-0067
識別號： ISSN: 1661-6596
識別號： EISSN: 1422-0067
識別號： DOI: 10.3390/ijms14058719
識別號： PMID: 23615467 |
| 顯示於類別: | [生命科學系] 期刊論文
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