Improving pharmaceutical protein production in Oryza sativa

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題名:	Improving pharmaceutical protein production in Oryza sativa
作者:	陸重安;Kuo, Yu-Chieh;Tan, Chia-Chun;Ku, Jung-Ting;Hsu, Wei-Cho;Su, Sung-Chieh;Lu, Chung-An;Huang, Li-Fen
貢獻者:	生醫理工學院生命科學系
關鍵詞:	Biotechnology - methods;Gene Expression;Humans;Oryza - metabolism;Plants, Genetically Modified;Recombinant Proteins - biosynthesis;Recombinant Proteins - therapeutic use;Review
日期:	2013-01-01
上傳時間:	2026-04-23 11:13:05 (UTC+8)
出版者:	MDPI Multidisciplinary Digital Publishing Institute;Switzerland: MDPI AG
摘要:	摘要： Application of plant expression systems in the production of recombinant proteins has several advantages, such as low maintenance cost, absence of human pathogens, and possession of complex post-translational glycosylation capabilities. Plants have been successfully used to produce recombinant cytokines, vaccines, antibodies, and other proteins, and rice (Oryza sativa) is a potential plant used as recombinant protein expression system. After successful transformation, transgenic rice cells can be either regenerated into whole plants or grown as cell cultures that can be upscaled into bioreactors. This review summarizes recent advances in the production of different recombinant protein produced in rice and describes their production methods as well as methods to improve protein yield and quality. Glycosylation and its impact in plant development and protein production are discussed, and several methods of improving yield and quality that have not been incorporated in rice expression systems are also proposed. Finally, different bioreactor options are explored and their advantages are analyzed. 其他題名： Int J Mol Sci 出版者： Switzerland: MDPI AG 出版日期： 2013-04-24 出處： International journal of molecular sciences, 2013, Vol.14 (5), p.8719-8739 資源來源： Publicly Available Content Database 版權： Copyright MDPI AG 2013 版權： 2013 by the authors; licensee MDPI, Basel, Switzerland 2013 識別號： ISSN: 1422-0067 識別號： ISSN: 1661-6596 識別號： EISSN: 1422-0067 識別號： DOI: 10.3390/ijms14058719 識別號： PMID: 23615467
顯示於類別:	[生命科學系] 期刊論文

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