Interferon gamma polymorphisms associated with susceptibility to tuberculosis in a Han Taiwanese population

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题名:	Interferon gamma polymorphisms associated with susceptibility to tuberculosis in a Han Taiwanese population
作者:	高永旭;Lee, Shih-Wei;Chuang, Tzu-Yi;Huang, Hsiu-Han;Lee, Kuei-Fang;Chen, Tina Tu-Wen;Kao, Yung-Hsi;Wu, Lawrence Shih-Hsin
贡献者:	生醫理工學院生命科學系
关键词:	Adult;Aged;Aged, 80 and over;Case-Control Studies;Ethnic Groups;Female;Gene Frequency;Genetic Predisposition to Disease;Genotype;Humans;IFN-γ;Infectious Disease;Interferon-gamma - genetics;Male;Medical Education;Middle Aged;Mycobacterium;Polymerase Chain Reaction;Polymorphism;Polymorphism, Single Nucleotide;Taiwan;Tuberculosis;Tuberculosis - genetics;Tuberculosis - immunology
日期:	2015-08-01
上传时间:	2026-04-23 11:13:10 (UTC+8)
出版者:	Elsevier Taiwan LLC;England: Elsevier B.V
摘要:	摘要： Polymorphisms of the interferon gamma (IFN-γ) gene are associated with the risk of tuberculosis (TB) in different populations. However, the genetic susceptibility to TB in Han Chinese living in Taiwan is still unknown. The purpose of this study is to evaluate whether the polymorphisms of the IFN-γ gene are associated with TB in Han Taiwanese. A total of 200 TB patients and 202 age-matched non-TB individuals were enrolled. Five tag single nucleotide polymorphisms (tSNPs) and rs2430561 (+874) of IFN-γ were selected from a public database. The genotypes were determined using polymerase chain reaction assays. Three IFN-γ polymorphisms in intron 3, rs1861494 and rs2069718, and rs2430561 in interon 1 were strongly associated with TB. The C carrier (CT+TT) of rs1861494, TT homozygous of rs2069718, and AA homozygous of rs2430561 were risk genotypes for susceptibility to TB. The IFN-γ polymorphisms, rs1861494, rs2069718, and rs2430561, may confer the risk of TB in Han Taiwanese. 其他題名： J Microbiol Immunol Infect 出版者： England: Elsevier B.V 出版日期： 2015-08-01 出處： Journal of microbiology, immunology and infection, 2015-08, Vol.48 (4), p.376-380 資源來源： Elsevier ScienceDirect Journals 版權： 2013 版權： Copyright © 2013. Published by Elsevier B.V. 識別號： ISSN: 1684-1182 識別號： ISSN: 1995-9133 識別號： EISSN: 1995-9133 識別號： DOI: 10.1016/j.jmii.2013.11.009 識別號： PMID: 24529854
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