New dimension of glucocorticoids in cancer treatment

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Title:	New dimension of glucocorticoids in cancer treatment
Authors:	王陸海;Lin, Kai-Ti;Wang, Lu-Hai
Contributors:	生醫理工學院生命科學系
Keywords:	Animals;Anti-Inflammatory Agents - therapeutic use;Glucocorticoid receptor;Glucocorticoids;Glucocorticoids - therapeutic use;Humans;Inflammation;Metastasis;microRNA;Neoplasms - drug therapy;Neoplasms - immunology;Neoplasms - metabolism;Receptors, Glucocorticoid - metabolism;Signal Transduction - drug effects;Tumor
Date:	2016-01-01
Issue Date:	2026-04-23 11:13:32 (UTC+8)
Publisher:	Elsevier Inc.;United States: Elsevier Inc
Abstract:	摘要： Glucocorticoids have been used in clinical oncology for over half a century. The clinical applications of glucocorticoids in oncology are mainly dependent on their pro-apoptotic action to treat lymphoproliferative disorders, and also on alleviating side effects induced by chemotherapy or radiotherapy in non-hematologic cancer types. Researches in the past few years have begun to unveil the profound complexity of glucocorticoids signaling and have contributed remarkably on therapeutic strategies. However, it remains striking and puzzling how glucocorticoids use different mechanisms in different cancer types and different targets to promote or inhibit tumor progression. In this review, we provide an update on glucocorticoids and its receptor, GR-mediated signaling and highlight some of the latest findings on the actions of glucocorticoids signaling during tumor progression and metastasis. 其他題名： Steroids 出版者： United States: Elsevier Inc 出版日期： 2016-07-01 出處： Steroids, 2016-07, Vol.111, p.84-88 版權： 2016 The Authors 版權： Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved. 識別號： ISSN: 0039-128X 識別號： ISSN: 1878-5867 識別號： EISSN: 1878-5867 識別號： DOI: 10.1016/j.steroids.2016.02.019 識別號： PMID: 26930575
Appears in Collections:	[Department of Life Science] journal & Dissertation

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