Quantum dots induced interferon beta expression via TRIF-dependent signaling pathways by promoting endocytosis of TLR4

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題名:	Quantum dots induced interferon beta expression via TRIF-dependent signaling pathways by promoting endocytosis of TLR4
作者:	羅月霞;Ho, Chia-Chi;Luo, Yueh-Hsia;Chuang, Tsung-Hsien;Lin, Pinpin
貢獻者:	生醫理工學院生命科學系
關鍵詞:	Adaptor Proteins, Vesicular Transport - agonists;Adaptor Proteins, Vesicular Transport - metabolism;Animals;Cell Line;Emergency;endocytosis;Endocytosis - drug effects;Endocytosis - physiology;Gene Expression Regulation;IFN-β;Immune systems;immunomodulation;Inflammation;Inhibitors;Interferon;interferon-beta;Interferon-beta - agonists;Interferon-beta - biosynthesis;Lungs;macrophages;Male;messenger RNA;Mice;Mice, Inbred ICR;nanoparticles;Pathways;Proteins;QD705;Quantum dots;Quantum Dots - toxicity;Semiconductors;signal transduction;Signal Transduction - drug effects;Signal Transduction - physiology;small interfering RNA;TLR4;Toll-like receptor 4;Toll-Like Receptor 4 - agonists;Toll-Like Receptor 4 - metabolism;TRIF
日期:	2016-02-17
上傳時間:	2026-04-23 11:13:40 (UTC+8)
出版者:	Ireland: Elsevier Ireland Ltd
摘要:	摘要： Quantum dots (QDs) are nano-sized semiconductors. Previously, intratracheal instillation of QD705s induces persistent inflammation and remodeling in the mouse lung. Expression of interferon beta (IFN-β), involved in tissue remodeling, was induced in the mouse lung. The objective of this study was to understand the mechanism of QD705 induced interferon beta (IFN-β) expression. QD705-COOH and QD705-PEG increased IFN-β and IP-10 mRNA levels during day1 to 90 post-exposure in mouse lungs. QD705-COOH increased IFN-β expression via Toll/interleukin-1 receptor domain-containing adapter protein (TRIF) dependent Toll-like receptor (TLR) signaling pathways in macrophages RAW264.7. Silencing TRIF expression with siRNA or co-treatment with a TRIF inhibitor tremendously abolished QD705s-induced IFN-β expression. Co-treatment with a TLR4 inhibitor completely prevented IFN-β induction by QD705-COOH. QD705-COOH readily entered cells, and co-treatment with either inhibitors of endocytosis or intracellular TLRs prevented IFN-β induction. Thus, activation of the TRIF dependent TLRs pathway by promoting endocytosis of TLR4 is one of the mechanisms for immunomodulatory effects of nanoparticles. 其他題名： Toxicology 出版者： Ireland: Elsevier Ireland Ltd 出版日期： 2016-02-17 出處： Toxicology (Amsterdam), 2016-02, Vol.344-346, p.61-70 版權： 2016 Elsevier Ireland Ltd 版權： Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. 識別號： ISSN: 0300-483X 識別號： ISSN: 1879-3185 識別號： EISSN: 1879-3185 識別號： DOI: 10.1016/j.tox.2016.02.005 識別號： PMID: 26925925
顯示於類別:	[生命科學系] 期刊論文

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