Sorafenib inhibits TPA-induced MMP-9 and VEGF expression via suppression of ERK/NF-κB pathway in hepatocellular carcinoma cells

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Title:	Sorafenib inhibits TPA-induced MMP-9 and VEGF expression via suppression of ERK/NF-κB pathway in hepatocellular carcinoma cells
Authors:	許斐婷;Chiang, I-Tsang;Liu, Yu-Chang;Wang, Wei-Hsun;Hsu, Fei-Ting;Chen, Hong-Wen;Lin, Wuu-Jyh;Chang, Wen-Yi;Hwang, Jeng-Jong
Contributors:	生醫理工學院生命科學系
Keywords:	Base Sequence;Benzenesulfonates - pharmacology;Carcinoma, Hepatocellular - enzymology;Carcinoma, Hepatocellular - metabolism;Carcinoma, Hepatocellular - pathology;Cell Line, Tumor;DNA Primers;Electrophoretic Mobility Shift Assay;Extracellular Signal-Regulated MAP Kinases - metabolism;Humans;Liver Neoplasms - enzymology;Liver Neoplasms - metabolism;Liver Neoplasms - pathology;Matrix Metalloproteinase 9 - drug effects;Matrix Metalloproteinase 9 - metabolism;NF-kappa B - metabolism;Niacinamide - analogs & derivatives;Phenylurea Compounds;Pyridines - pharmacology;Reverse Transcriptase Polymerase Chain Reaction;Tetradecanoylphorbol Acetate - pharmacology;Vascular Endothelial Growth Factor A - antagonists & inhibitors;Vascular Endothelial Growth Factor A - metabolism
Date:	2012-01-01
Issue Date:	2026-04-23 11:13:50 (UTC+8)
Publisher:	International Institute of Anticancer Research;Greece
Abstract:	摘要： Invasion by hepatocellular carcinoma (HCC) has been reported to occur via the up-regulation of nuclear factor-kappaB (NF-κB). Sorafenib can improve the overall survival in patients with HCC, however, the association of its inhibitory mechanisms with the inactivation of NF-κB remains unclear. Here, Huh7 cell line transfected with NF-κB-luc2 vector was used to study the effects of sorafenib on NF-κB activity, on expressions of matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF), which were induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). TPA increased the NF-κB activity and the expressions of MMP-9 and VEGF significantly, but its effects were suppressed by sorafenib in a dose-dependent manner. Similar results were found with PD98059, an inhibitor of extracellular signal-regulated kinase (ERK). Furthermore, transfection of Huh7 cell with an inhibitor of kappaB-α mutant vector, led to reduced TPA-induced MMP-9 and VEGF mRNA expressions. Sorafenib inhibits TPA-induced MMP-9 and VEGF expressions via the suppression of ERK/NF-κB pathway in HCC cells. 其他題名： In Vivo 出版者： Greece 出版日期： 2012-07-01 出處： In vivo (Athens), 2012-07, Vol.26 (4), p.671 識別號： ISSN: 1791-7549 識別號： EISSN: 1791-7549 識別號： PMID: 22773582
Appears in Collections:	[Department of Life Science] journal & Dissertation

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