Synergistic effect of sorafenib with ionizing radiation on human oral cancer cells

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题名:	Synergistic effect of sorafenib with ionizing radiation on human oral cancer cells
作者:	許斐婷;Hsu, Fei-Ting;Chang, Betty;Chiang, I-Tsang;Wu, Tai-Hsien;Hwang, Jeng-Jong
贡献者:	生醫理工學院生命科學系
关键词:	Antineoplastic Agents - pharmacology;Carcinoma, Squamous Cell - genetics;Carcinoma, Squamous Cell - metabolism;Carcinoma, Squamous Cell - pathology;Cell Line, Tumor;Cell Proliferation - drug effects;Cell Proliferation - radiation effects;Dose-Response Relationship, Drug;Enzyme Activation - drug effects;Gene Expression Regulation, Neoplastic - drug effects;Humans;Mouth Neoplasms - genetics;Mouth Neoplasms - metabolism;Mouth Neoplasms - pathology;NF-kappa B - genetics;NF-kappa B - metabolism;Niacinamide - analogs & derivatives;Niacinamide - pharmacology;Phenylurea Compounds - pharmacology;Phosphorylation - drug effects;Protein Kinase Inhibitors - pharmacology;Radiation Tolerance - drug effects;Radiation, Ionizing
日期:	2014-09-01
上传时间:	2026-04-23 11:13:56 (UTC+8)
出版者:	International Institute of Anticancer Research;Greece
摘要:	摘要： Although anticancer effects of sorafenib on renal, liver and colon carcinomas are well-known, its combination effect with ionizing radiation on oral squamous cell carcinoma (OSCC) is unclear. Herein human SAS cells, an OSCC cell line, were used in order to elucidate this combination effect. Both SAS and SAS/nuclear factor kappa-B-luciferase (SAS/NF-κB-luc2) cell lines were used in the study. Cell viability, NF-κB activation, and protein expression of NF-κB downstream effectors were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, NF-κB-luc2 reporter gene system, NF-κB/DNA binding activity and western blotting. Sorafenib significantly increased radiation-induced cytotoxicity and apoptosis via both mitochondrial-dependent and independent pathways. In addition, NF-κB activity and downstream effector protein expression induced by radiation was suppressed by sorafenib in SAS/NF-κB-luc2 cells. Combination of sorafenib with radiation for the treatment of human OSCC shows a synergistic effect via suppression of radiation-induced NF-κB activity and its regulated downstream effector proteins. 其他題名： In Vivo 出版者： Greece 出版日期： 2014-09 出處： In vivo (Athens), 2014-09, Vol.28 (5), p.925 版權： Copyright © 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. 識別號： ISSN: 1791-7549 識別號： EISSN: 1791-7549 識別號： PMID: 25189909
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