Toll-like receptor 3 expression inhibits cell invasion and migration and predicts a favorable prognosis in neuroblastoma

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Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/102645

Title:	Toll-like receptor 3 expression inhibits cell invasion and migration and predicts a favorable prognosis in neuroblastoma
Authors:	吳沛翊;Hsu, Wen-Ming;Huang, Chao-Cheng;Wu, Pei-Yi;Lee, Hsinyu;Huang, Min-Chuan;Tai, Ming-Hong;Chuang, Jiin-Haur
Contributors:	生醫理工學院生命科學系
Keywords:	actin;Actins;Actins - metabolism;administration & dosage;Age;agonists;Apoptosis;Apoptosis - drug effects;Apoptosis - physiology;biosynthesis;Bone marrow;Breast cancer;Cancer therapies;Cell adhesion & migration;Cell culture;Cell Line, Tumor;cell movement;Cell Movement - drug effects;Cell Movement - physiology;Child;Child, Preschool;drug effects;Female;GAP-43 Protein;GAP-43 Protein - biosynthesis;Gene Expression;genetics;Hematology, Oncology and Palliative Medicine;Histology;Humans;immunohistochemistry;in vitro studies;Infant;Infant, Newborn;Male;Medical prognosis;metabolism;Migration;Multivariate analysis;Neuroblastoma;Neuroblastoma - genetics;Neuroblastoma - metabolism;Neuroblastoma - pathology;pathology;Patients;pharmacology;physiology;Poly I-C;Poly I-C - pharmacology;Polymerase chain reaction;Prognosis;pseudopodia;RNA, Small Interfering;RNA, Small Interfering - administration & dosage;RNA, Small Interfering - genetics;Signal Transduction;Studies;Toll-Like Receptor 3;Toll-Like Receptor 3 - agonists;Toll-Like Receptor 3 - biosynthesis;Toll-Like Receptor 3 - genetics;Tumors
Date:	2013-08-19
Issue Date:	2026-04-23 11:14:08 (UTC+8)
Publisher:	Elsevier Ireland Ltd;Ireland: Elsevier Ireland Ltd
Abstract:	摘要： •Positive TLR3 expression was associated with favorable histology and prognosis in neuroblastoma.•Activation of TLR3 by agonist polyinosinic:polycytidylic acid [poly(I:C)] is effective to suppress cell migration and invasion.•Poly(I:C) may decrease organized assembly of F-actin and filopodia formation, in TLR3-expressing SK-N-AS cells.•Poly(I:C) promotes GAP-43 expression, a marker of neuronal differentiation, in SK-N-AS cells.•The above effects of poly(I:C) on SK-N-AS neuroblastoma cells could be reversed by TLR3-targeting siRNA treatment. To evaluate the clinical significance of TLR3 expression on neuroblastomas, we performed immunohistochemical study on archival tissues and in vitro studies on neuroblastoma cell lines. The results showed that positive TLR3 expression was associated with favorable histology and prognosis. Activation of TLR3 by polyinosinic:polycytidylic acid [poly(I:C)] treatment is effective to suppress cell migration and invasion and to decrease organized assembly of F-actin and filopodia formation, in TLR3-expressing SK-N-AS cells, which could be reversed by TLR3-targeting siRNA treatment. TLR3 agonist poly(I:C) promotes GAP-43 expression also in SK-N-AS cells only. Taken together, TLR3 could serve to predict favorable behavior in neuroblastomas. 其他題名： Cancer Lett 出版者： Ireland: Elsevier Ireland Ltd 出版日期： 2013-08-19 出處： Cancer Letters, 2013-08, Vol.336 (2), p.338-346 版權： 2013 Elsevier Ireland Ltd 版權： Elsevier Ireland Ltd 版權： Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. 版權： Copyright Elsevier Limited Aug 19, 2013 識別號： ISSN: 0304-3835 識別號： ISSN: 1872-7980 識別號： EISSN: 1872-7980 識別號： DOI: 10.1016/j.canlet.2013.03.024 識別號： PMID: 23541683
Appears in Collections:	[Department of Life Science] journal & Dissertation

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