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| 題名: | A nonlinear dynamic approach reveals a long-term stroke effect on cerebral blood flow regulation at multiple time scales |
| 作者: | 羅孟宗;Hu, Kun;Lo, Men-Tzung;Peng, Chung-Kang;Liu, Yanhui;Novak, Vera |
| 貢獻者: | 生醫理工學院生醫科學與工程學系 |
| 關鍵詞: | Aged;Aged, 80 and over;Biology;Biomathematics;Blood flow;Blood pressure;Brain damage;Case-Control Studies;Cerebrovascular Circulation - physiology;Cerebrum;Computational Biology - methods;Computer Simulation;Diabetes;Differential equations;Female;Flow velocity;Fourier transforms;Grants;Health aspects;Heart rate;Homeostasis - physiology;Humans;Male;Mathematics;Medicine;Middle Aged;Nonlinear Dynamics;Physics;Physiological aspects;Physiology;Stroke;Stroke - physiopathology;Studies |
| 日期: | 2012-07-01 |
| 上傳時間: | 2026-04-23 11:14:52 (UTC+8) |
| 出版者: | Public Library of Science;United States: Public Library of Science (PLoS) |
| 摘要: | 摘要： Cerebral autoregulation (CA) is an important vascular control mechanism responsible for relatively stable cerebral blood flow despite changes of systemic blood pressure (BP). Impaired CA may leave brain tissue unprotected against potentially harmful effects of BP fluctuations. It is generally accepted that CA is less effective or even inactive at frequencies >∼0.1 Hz. Without any physiological foundation, this concept is based on studies that quantified the coupling between BP and cerebral blood flow velocity (BFV) using transfer function analysis. This traditional analysis assumes stationary oscillations with constant amplitude and period, and may be unreliable or even invalid for analysis of nonstationary BP and BFV signals. In this study we propose a novel computational tool for CA assessment that is based on nonlinear dynamic theory without the assumption of stationary signals. Using this method, we studied BP and BFV recordings collected from 39 patients with chronic ischemic infarctions and 40 age-matched non-stroke subjects during baseline resting conditions. The active CA function in non-stroke subjects was associated with an advanced phase in BFV oscillations compared to BP oscillations at frequencies from ∼0.02 to 0.38 Hz. The phase shift was reduced in stroke patients even at > = 6 months after stroke, and the reduction was consistent at all tested frequencies and in both stroke and non-stroke hemispheres. These results provide strong evidence that CA may be active in a much wider frequency region than previously believed and that the altered multiscale CA in different vascular territories following stroke may have important clinical implications for post-stroke recovery. Moreover, the stroke effects on multiscale cerebral blood flow regulation could not be detected by transfer function analysis, suggesting that nonlinear approaches without the assumption of stationarity are more sensitive for the assessment of the coupling of nonstationary physiological signals.
其他題名： PLoS Comput Biol
出版者： United States: Public Library of Science (PLoS)
出版日期： 2012-07-01
出處： PLoS computational biology, 2012-07, Vol.8 (7), p.e1002601
資源來源： DOAJ (selected full-text)
版權： COPYRIGHT 2012 Public Library of Science
版權： 2012 Hu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Hu K, Lo M-T, Peng C-K, Liu Y, Novak V (2012) A Nonlinear Dynamic Approach Reveals a Long-Term Stroke Effect on Cerebral Blood Flow Regulation at Multiple Time Scales. PLoS Comput Biol 8(7): e1002601. doi:10.1371/journal.pcbi.1002601
版權： Hu et al. 2012
識別號： ISSN: 1553-7358
識別號： ISSN: 1553-734X
識別號： EISSN: 1553-7358
識別號： DOI: 10.1371/journal.pcbi.1002601
識別號： PMID: 22807666 |
| 顯示於類別: | [生醫科學與工程學系] 期刊論文
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