Association between parathyroid hormone levels and inflammatory markers among US adults

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Title:	Association between parathyroid hormone levels and inflammatory markers among US adults
Authors:	許藝瓊;Hsu, Yi-Chiung;Liu, Tsang-Pai;Liu, Chien-Liang;Cheng, Shih-Ping;Lee, Jie-Jen
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Adult;Aged;C-Reactive Protein - metabolism;Clinical Study;Cross-Sectional Studies;Erythrocytes - cytology;Female;Glomerular Filtration Rate;Health aspects;Humans;Inflammation;Inflammation - blood;Inflammation - epidemiology;Leukocytes - cytology;Linear Models;Male;Middle Aged;Nutrition Surveys;Odds Ratio;Parathyroid hormone;Parathyroid Hormone - blood;Physiological aspects;United States - epidemiology
Date:	2014-01-01
Issue Date:	2026-04-23 11:15:11 (UTC+8)
Publisher:	Hindawi Publishing Corporation;Cairo, Egypt: Hindawi Limiteds
Abstract:	摘要： Background and Aims. High levels of parathyroid hormone (PTH) appear to be associated with an increased mortality. Previous studies concerning the relationship of inflammatory markers with hyperparathyroidism have yielded inconsistent results. This study investigated whether serum PTH concentrations were independently associated with several inflammatory markers among the US adults. Materials and Methods. Using data from the National Health and Nutrition Examination Survey, we examined the relation between serum PTH and C-reactive protein (CRP), red cell distribution width (RDW), and platelet-to-lymphocyte ratio (PLR) levels with weighted linear regression. Additionally, we examined the relation with increased modified Glasgow Prognostic Score (mGPS) by using weighted logistic regression. Results. CRP, RDW, and PLR values increased with increasing serum PTH concentration. After extensively adjusting for covariates, CRP and RDW increased linearly and across PTH categories (all P < 0.001 ), while PLR marginally increased ( P = 0.190 and P = 0.095 using PTH as a categorical and continuous variable, resp.). The odds ratio of increased mGPS was 1.11 and 1.31 across PTH categories and with increasing PTH levels continuously. Conclusion. These nationally representative data indicate that serum PTH levels are independently associated with several inflammatory markers in the US population. The casual relationship between PTH levels and inflammation remains to be elucidated. 其他題名： Mediators Inflamm 出版者： Cairo, Egypt: Hindawi Limiteds 出版日期： 2014-01-01 出處： Mediators of Inflammation, 2014-01, Vol.2014 (7), p.1-8 資源來源： Chinese Electronic Periodical Services (CEPS) 版權： Copyright © 2014 Shih-Ping Cheng et al. 版權： COPYRIGHT 2014 John Wiley & Sons, Inc. 版權： COPYRIGHT 2014 Hindawi Limited 版權： Copyright © 2014 Shih-Ping Cheng et al. 2014 識別號： ISSN: 0962-9351 識別號： ISSN: 1466-1861 識別號： EISSN: 1466-1861 識別號： DOI: 10.1155/2014/709024 識別號： PMID: 24782595
Appears in Collections:	[Department of Biomedical Sciences and Engineering ] journal & Dissertation

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