Comparison the prognostic value of galectin-3 and serum markers of cardiac extracellular matrix turnover in patients with chronic systolic heart failure

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Title:	Comparison the prognostic value of galectin-3 and serum markers of cardiac extracellular matrix turnover in patients with chronic systolic heart failure
Authors:	羅孟宗;Chang, Yi-Yao;Chen, Aaron;Wu, Xue-Ming;Hsu, Tse-Pin;Liu, Li-Yu Daisy;Chen, Yenh-Hsein;Wu, Yen-Wen;Lin, Hung-Ju;Hsu, Ron-Bin;Lee, Chi-Ming;Wang, Shoei-Shen;Lo, Men-Tzung;Chen, Ming-Fong;Lin, Yen-Hung
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Aged;Female;Galectin 3 - blood;Heart Failure, Systolic - blood;Heart Failure, Systolic - pathology;Humans;Male;Matrix Metalloproteinase 2 - blood;Matrix Metalloproteinase 9 - blood;Middle Aged;Natriuretic Peptide, Brain - blood;Peptide Fragments - blood;Predictive Value of Tests;Procollagen - blood;Research Paper;Tissue Inhibitor of Metalloproteinase-1 - blood
Date:	2014-08-13
Issue Date:	2026-04-23 11:15:21 (UTC+8)
Publisher:	Ivyspring International Publisher;Australia: Ivyspring International Publisher
Abstract:	摘要： Galectin-3 (Gal-3) shows the ability of survival prediction in heart failure (HF) patients. However, Gal-3 is strongly associated with serum markers of cardiac extracellular matrix (ECM) turnover. The aim of this study is to compare the impact of Gal-3 and serum markers of cardiac ECM turnover on prognostic prediction of chronic systolic HF patients. Serum Gal-3, brain natriuretic peptide (BNP), extracellular matrix including type I and III aminoterminal propeptide of procollagen (PINP and PIIINP), matrix metalloproteinase-2, 9 (MMP-2, 9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) were analyzed. Cox regression analysis was used for survival analysis. A total of 105 (81 male) patients were enrolled. During 980±346 days follow-up, 17 patients died and 36 episodes of HF admission happened. Mortality of these patients was significantly associated with the log PIIINP (β= 15.380; P=0.042), log TIMP-1(β= 44.530; P=0.003), log MMP-2 (β= 554.336; P<0.001), log BNP (β= 28.273; P=0.034). Log Gal-3 (β= 7.484; P=0.066) is borderline associated with mortality. Mortality or first HF admission of these patients was significantly associated with the log TIMP-1(β= 16.496; P=0.006), log MMP-2 (β= 221.864; P<0.001), log BNP (β= 5.999; P=0.034). Log Gal-3 (β= 4.486; P=0.095) only showed borderline significance. In several models adjusting clinical parameters, log MMP-2 was significantly associated with clinical outcome. In contrast, log Gal-3 was not. The prognostic strength of MMP-2 to clinical outcome prediction in HF patients is stronger than Gal-3. 其他題名： Int J Med Sci 出版者： Australia: Ivyspring International Publisher 出版日期： 2014-01-01 出處： International journal of medical sciences, 2014-01, Vol.11 (11), p.1098-1106 資源來源： PubMed Central Open Access 版權： Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. 2014 識別號： ISSN: 1449-1907 識別號： EISSN: 1449-1907 識別號： DOI: 10.7150/ijms.8083 識別號： PMID: 25170292
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