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| 題名: | Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity |
| 作者: | 馬念涵;Yen, Chia-I;Liu, Szu-Mam;Lo, Wei-Shang;Wu, Jhe-Wei;Liu, Yi-Hsin;Chein, Rong-Jie;Yang, Renqiang;Wu, Kevin C.-W.;Hwu, Jih Ru;Ma, Nianhan;Shieh, Fa-Kuen |
| 貢獻者: | 生醫理工學院生醫科學與工程學系 |
| 關鍵詞: | Aldehydes - chemistry;Amination;Assaying;Charging;Chemistry;Correlation;Crystals;Cytotoxicity;drug carriers;Imidazoles - chemistry;Imidazoles - toxicity;In vitro methods and tests;In vitro testing;Integrity;Membranes;Metal-organic frameworks;Models, Molecular;Nanocrystals;Nanoparticles - chemistry;Perturbation;post-modification;Sulfhydryl Compounds - chemistry;Thiols;Toxicity;Uptakes;Zeolites - chemistry;Zeolites - toxicity;ZIF-90 |
| 日期: | 2016-02-24 |
| 上傳時間: | 2026-04-23 11:15:31 (UTC+8) |
| 出版者: | Wiley-VCH Verlag;Germany: Blackwell Publishing Ltd |
| 摘要: | 摘要： Using a simple method, the aldehyde groups of zeolitic imidazolate framework‐90 (ZIF‐90) nanocrystals were converted into carboxyl, amino, and thiol groups, without affecting the integrity of the framework. Notably, for the first time, correlations between functionality and cytotoxicity are also demonstrated via in vitro cytotoxicity assays. The positive charged aminated‐ZIF‐90 presumably results in either perturbation of cell membrane, more efficient cell uptake, or both. Therefore, the half‐maximal effective (EC50) concentration of aminated‐ZIF‐90 has a higher cytotoxicity of about 30 μg mL−1. Supermodification: ZIF‐90 (zeolitic imidazolate framework‐90) nanocrystals were substituted with carboxyl, amino, and thiol groups without affecting framework integrity. In vitro cytotoxicity assays reveals that the positively charged aminated ZIF‐90 presumably results in perturbation of cell membrane and/or more efficient cell uptake. The half‐maximal effective (EC50) concentration of aminated‐ZIF‐90 has a higher cytotoxicity (ca. 30 μg mL−1).
其他題名： Chem. Eur. J
出版者： Germany: Blackwell Publishing Ltd
出版日期： 2016-02-24
出處： Chemistry : a European journal, 2016-02, Vol.22 (9), p.2925-2929
版權： 2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
版權： 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
版權： 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
識別號： ISSN: 0947-6539
識別號： ISSN: 1521-3765
識別號： EISSN: 1521-3765
識別號： DOI: 10.1002/chem.201505005
識別號： PMID: 26756283
識別號： CODEN: CEUJED |
| 顯示於類別: | [生醫科學與工程學系] 期刊論文
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