EBV oncogene N-LMP1 induces CD4 T cell-mediated angiogenic blockade in the murine tumor model

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Title:	EBV oncogene N-LMP1 induces CD4 T cell-mediated angiogenic blockade in the murine tumor model
Authors:	劉淑貞;Wu, Tzong-Shoon;Wang, Lian-Chen;Liu, Shu-Chen;Hsu, Ting-Yu;Lin, Chun-Yen;Feng, Gou-Jin;Chen, Jian-Ming;Liu, Hao-Ping;Chung, I-Che;Yen, Tzu-Chen;Chang, Yu-Sun;Liao, Shuen-Kuei;Chang, Chen;Chow, Kai-Ping N
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Animals;CD4-Positive T-Lymphocytes - immunology;CD4-Positive T-Lymphocytes - metabolism;CD4-Positive T-Lymphocytes - virology;Cell Line, Tumor;Dendritic Cells - immunology;Disease Models, Animal;Disease Progression;Epitopes, T-Lymphocyte - chemistry;Epitopes, T-Lymphocyte - immunology;Epstein-Barr virus;Herpesvirus 4, Human - genetics;Herpesvirus 4, Human - immunology;Lymphocyte Activation - immunology;Male;Mice;Mice, Knockout;Neoplasms - immunology;Neoplasms - metabolism;Neoplasms - pathology;Neoplasms - virology;Neovascularization, Pathologic - immunology;Peptide Fragments - chemistry;Peptide Fragments - immunology;Viral Matrix Proteins - chemistry;Viral Matrix Proteins - genetics;Viral Matrix Proteins - immunology
Date:	2015-01-01
Issue Date:	2026-04-23 11:15:48 (UTC+8)
Publisher:	American Association of Immunologists;United States
Abstract:	摘要： Antivascular immunity may provide long-term protection by preventing neovascularization that precedes tumor progression. Although the tumorigenesis promoted by EBV-encoded oncogene latent membrane protein 1 derived from Taiwanese nasopharyngeal carcinoma (N-LMP1) has been demonstrated, the potential of N-LMP1 for inducing immune surveillance remains elusive. In this article, we describe the immunogenicity of N-LMP1 (1510) and its induction of antivascular immunity in a transplantable tumor model in immunocompetent BALB/c mice. The immunogenicity of N-LMP1 was evaluated on the basis of tumor rejection following immunization. The impact of the immunization on the dynamics of tumor angiogenesis was assessed by temporal noninvasive dynamic contrast-enhanced magnetic resonance imaging and was further confirmed by histologic study and vascular count. Through the experiments of in vivo depletion and adoptive transfer, CD4 T cells were identified as effectors that depend on IFN-γ for tumor prevention. The response was further verified by the identification of an MHC H-2 I-Ed–restricted peptide derived from N-LMP1 and by the immunization of mice with N-LMP1 peptide–loaded dendritic cells. These studies provide insight into N-LMP1–specific immunity in vivo, which suggests that CD4 T cells may play an important role in angiogenic surveillance against LMP1–associated cancer via tumor stroma targeting. 其他題名： J Immunol 出版者： United States 出版日期： 2015-05-01 出處： The Journal of immunology (1950), 2015-05, Vol.194 (9), p.4577-4587 版權： Copyright © 2015 by The American Association of Immunologists, Inc. 識別號： ISSN: 0022-1767 識別號： ISSN: 1550-6606 識別號： EISSN: 1550-6606 識別號： DOI: 10.4049/jimmunol.1400794 識別號： PMID: 25847974
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