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| 題名: | Evaluation of the Chinese medicinal herb, Graptopetalum paraguayense, as a therapeutic treatment for liver damage in rat models |
| 作者: | 蘇立仁;Huang, Chi-Ying F.;Hsu, Shih-Lan;Tseng, Tzu-Ling;Hsieh, Hui-Chu;Yuo, Ya-Ling;Huang, Shiu-Feng;Yang, Chih-Hsueh;Su, Li-Jen;Chen, Chang-Han |
| 貢獻者: | 生醫理工學院生醫科學與工程學系 |
| 關鍵詞: | Alcoholism;Animal models;Bile;Bioinformatics;BTG2 protein;Cirrhosis;Cytotoxicity;DNA microarrays;Drug development;EGR-1 protein;Ethanol;Fibrosis;Gene expression;Graptopetalum paraguayense;Hepatitis;Hepatology;Herbal medicine;Hypertension;Liver;Liver cirrhosis;Liver diseases;Medicinal plants;Molecular modelling;Polymerase chain reaction;Rodents;Signal transduction;Stellate cells;Traditional Chinese medicine |
| 日期: | 2012-08-17 |
| 上傳時間: | 2026-04-23 11:16:00 (UTC+8) |
| 出版者: | Hindawi Publishing Corporation;Cairo, Egypt: Hindawi Publishing Corporation |
| 摘要: | 摘要： The incidence of cirrhosis is rising due to the widespread occurrence of chronic hepatitis, as well as the evident lack of an established therapy for hepatic fibrosis. In the search for hepatoprotective therapeutic agents, Graptopetalum paraguayense (GP) showed greater cytotoxicity toward hepatic stellate cells than other tested herbal medicines. Histopathological and biochemical analyses suggest that GP treatment significantly prevented DMN-induced hepatic inflammation and fibrosis in rats. Microarray profiling indicated that expression of most of metabolism- and cell growth and/or maintenance-related genes recovered to near normal levels following GP treatment as classified by gene ontology and LSM analysis, was observed. ANOVA showed that expression of 64% of 256 liver damage-related genes recovered significantly after GP treatment. By examining rat liver samples with Q-RT-PCR, five liver damage-related genes were identified. Among them, Egr1 and Nrg1 may serve as necroinflammatory markers, and Btg2 may serve as a fibrosis marker. Oldr1 and Hmgcs1 were up- and down-regulated markers, respectively. A publicly accessible website has been established to provide access to these data Identification of 44 necroinflammation-related and 62 fibrosis-related genes provides useful insight into the molecular mechanisms underlying liver damage and provides potential targets for the rational development of therapeutic drugs such as GP.
其他題名： Evid Based Complement Alternat Med
出版者： Cairo, Egypt: Hindawi Publishing Corporation
出版日期： 2012-01-01
出處： Evidence-based complementary and alternative medicine, 2012-01, Vol.2012 (2012), p.1-15
資源來源： ProQuest Open Access Content Collection
版權： Copyright © 2012 Li-Jen Su et al.
版權： Copyright © 2012 Li-Jen Su et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0
版權： Copyright © 2012 Li-Jen Su et al. 2012
識別號： ISSN: 1741-427X
識別號： ISSN: 1741-4288
識別號： EISSN: 1741-4288
識別號： DOI: 10.1155/2012/256561
識別號： PMID: 22811744 |
| 顯示於類別: | [生醫科學與工程學系] 期刊論文
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