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    請使用永久網址來引用或連結此文件: https://ir.lib.ncu.edu.tw/handle/987654321/102750


    題名: Fermentation of Propionibacterium acnes, a Commensal Bacterium in the Human Skin Microbiome, as Skin Probiotics against Methicillin-Resistant Staphylococcus aureus
    作者: 黃俊銘;Shu, Muya;Wang, Yanhan;Yu, Jinghua;Kuo, Sherwin;Coda, Alvin;Jiang, Yong;Gallo, Richard L.;Huang, Chun-Ming
    貢獻者: 生醫理工學院生醫科學與工程學系
    關鍵詞: Acne;Animals;Antibiotics;Bacteria;Bacterial infections;Biology;Commensals;Communicable diseases;Dermatology;Drug resistance;Fatty acids;Fermentation;Gene expression;Glycerol;Glycerol - metabolism;Humans;Hydrogen-Ion Concentration;Infectious diseases;Intestine;Lipids;Mathematics;Medical research;Medicine;Methicillin;Methicillin-Resistant Staphylococcus aureus - genetics;Methicillin-Resistant Staphylococcus aureus - metabolism;Mice;Mice, Inbred ICR;Microbial drug resistance;Microbiota;Microorganisms;Milk;Prevention;Probiotics;Probiotics - metabolism;Propionibacterium acnes;Propionibacterium acnes - genetics;Propionibacterium acnes - metabolism;Skin;Skin - metabolism;Skin - microbiology;Skin diseases;Skin resistance;Staphylococcal Skin Infections - metabolism;Staphylococcal Skin Infections - microbiology;Staphylococcal Skin Infections - prevention & control;Staphylococcus aureus;Staphylococcus aureus - metabolism;Staphylococcus aureus infections;Staphylococcus infections;Yogurt
    日期: 2013-02-06
    上傳時間: 2026-04-23 11:16:05 (UTC+8)
    出版者: Public Library of Science;United States: Public Library of Science (PLoS)
    摘要: 摘要: Bacterial interference creates an ecological competition between commensal and pathogenic bacteria. Through fermentation of milk with gut-friendly bacteria, yogurt is an excellent aid to balance the bacteriological ecosystem in the human intestine. Here, we demonstrate that fermentation of glycerol with Propionibacterium acnes (P. acnes), a skin commensal bacterium, can function as a skin probiotic for in vitro and in vivo growth suppression of USA300, the most prevalent community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). We also promote the notion that inappropriate use of antibiotics may eliminate the skin commensals, making it more difficult to fight pathogen infection. This study warrants further investigation to better understand the role of fermentation of skin commensals in infectious disease and the importance of the human skin microbiome in skin health.
    其他題名: PLoS One
    出版者: United States: Public Library of Science (PLoS)
    出版日期: 2013-02-06
    出處: PLoS ONE, 2013-02, Vol.8 (2), p.e55380-
    資源來源: Agricultural & Environmental Science Collection
    版權: COPYRIGHT 2013 Public Library of Science
    版權: 2013 Shu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
    版權: 2013 Shu et al 2013 Shu et al
    識別號: ISSN: 1932-6203
    識別號: EISSN: 1932-6203
    識別號: DOI: 10.1371/journal.pone.0055380
    識別號: PMID: 23405142
    顯示於類別:[生醫科學與工程學系] 期刊論文

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