Genotypes of cancer stem cells characterized by epithelial-to-mesenchymal transition and proliferation related functions

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Title:	Genotypes of cancer stem cells characterized by epithelial-to-mesenchymal transition and proliferation related functions
Authors:	馬念涵;Hsu, Chueh-Lin;Chung, Feng-Hsiang;Chen, Chih-Hao;Hsu, Tzu-Ting;Liu, Szu-Mam;Chung, Dao-Sheng;Hsu, Ya-Fen;Chen, Chien-Lung;Ma, Nianhan;Lee, Hoong-Chien
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	38;38/39;45;45/100;45/61;631/67/69;631/67/71;692/4028/67/69;Cancer;Cell proliferation;Colon;Datasets;Drug resistance;Gene expression;Genomes;Genotypes;Humanities and Social Sciences;Mesenchyme;multidisciplinary;Prostate;Science;Science (multidisciplinary);Stem cells
Date:	2016-09-06
Issue Date:	2026-04-23 11:16:10 (UTC+8)
Publisher:	Nature Publishing Group;London: Nature Publishing Group UK
Abstract:	摘要： Cancer stem cells (CSCs), or cancer cells with stem cell-like properties, generally exhibit drug resistance and have highly potent cancer inducing capabilities. Genome-wide expression data collected at public repositories over the last few years provide excellent material for studies that can lead to insights concerning the molecular and functional characteristics of CSCs. Here, we conducted functional genomic studies of CSC based on fourteen PCA-screened high quality public CSC whole genome gene expression datasets and, as control, four high quality non-stem-like cancer cell and non-cancerous stem cell datasets from the Gene Expression Omnibus database. A total of 6,002 molecular signatures were taken from the Molecular Signatures Database and used to characterize the datasets, which, under two-way hierarchical clustering, formed three genotypes. Type 1, consisting of mainly glia CSCs, had significantly enhanced proliferation, and significantly suppressed epithelial-mesenchymal transition (EMT), related functions. Type 2, mainly breast CSCs, had significantly enhanced EMT, but not proliferation, related functions. Type 3, composed of ovarian, prostate, and colon CSCs, had significantly suppressed proliferation related functions and mixed expressions on EMT related functions. 其他題名： Sci Rep 出版者： London: Nature Publishing Group UK 出版日期： 2016-09-06 出處： Scientific reports, 2016-09, Vol.6 (1), p.32523-32523, Article 32523 資源來源： Publicly Available Content Database 版權： The Author(s) 2016 版權： Copyright Nature Publishing Group Sep 2016 版權： Copyright © 2016, The Author(s) 2016 The Author(s) 識別號： ISSN: 2045-2322 識別號： EISSN: 2045-2322 識別號： DOI: 10.1038/srep32523 識別號： PMID: 27597445
Appears in Collections:	[Department of Biomedical Sciences and Engineering ] journal & Dissertation

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