In vivo treatment of propionibacterium acnes infection with liposomal lauric acids

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Title:	In vivo treatment of propionibacterium acnes infection with liposomal lauric acids
Authors:	黃俊銘;Pornpattananangkul, Dissaya;Fu, Victoria;Thamphiwatana, Soracha;Zhang, Li;Chen, Michael;Vecchio, James;Gao, Weiwei;Huang, Chun-Ming;Zhang, Liangfang
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Acids;Acne;Animals;Anti-Bacterial Agents - administration & dosage;Anti-Bacterial Agents - chemistry;Anti-Bacterial Agents - pharmacology;antimicrobial delivery;Bacteria;bacterial infection;Biocompatibility;Biomedical materials;Disease Models, Animal;free fatty acid;Gram-Positive Bacterial Infections - drug therapy;Gram-Positive Bacterial Infections - microbiology;In vivo testing;In vivo tests;Infections;Lauric acid;Lauric Acids - administration & dosage;Lauric Acids - chemistry;Lauric Acids - pharmacology;Liposomes - chemistry;Medical treatment;Mice;nanoparticle;Propionibacterium acnes;Propionibacterium acnes - drug effects;Skin - drug effects;Skin - pathology;Skin Diseases - drug therapy;Skin Diseases - microbiology;Surgical implants;Toxicity
Date:	2013-01-01
Issue Date:	2026-04-23 11:16:24 (UTC+8)
Publisher:	John Wiley and Sons Ltd;Weinheim: WILEY-VCH Verlag
Abstract:	摘要： Propionibacterium acnes (P. acnes) is a Gram‐positive bacterium strongly associated with acne infection. While many antimicrobial agents have been used in clinic to treat acne infection by targeting P. acnes, these existing anti‐acne agents usually produce considerable side effects. Herein, the development and evaluation of liposomal lauric acids (LipoLA) is reported as a new, effective and safe therapeutic agent for the treatment of acne infection. By incorporating lauric acids into the lipid bilayer of liposomes, it is observed that the resulting LipoLA readily fuse with bacterial membranes, causing effective killing of P. acnes by disrupting bacterial membrane structures. Using a mouse ear model, we demonstrated that the bactericidal property of LipoLA against P. acne is well preserved at physiological conditions. Topically applying LipoLA in a gel form onto the infectious sites leads to eradication of P. acnes bacteria in vivo. Further skin toxicity studies show that LipoLA does not induce acute toxicity to normal mouse skin, while benzoyl peroxide and salicylic acid, the two most popular over‐the‐counter acne medications, generate moderate to severe skin irritation within 24 h. These results suggest that LipoLA hold a high therapeutic potential for the treatment of acne infection and other P. acnes related diseases. This article reports the development and in vivo evaluation of liposomal lauric acids (LipoLA) as a new, effective, and safe nanotherapeutic agent for the treatment of Propionibacterium acnes infection. Using a mouse ear model, topically applying LipoLA in a gel form onto the infectious site results in completely killing the bacteria without inducing acute toxicity to normal skin. 其他題名： Advanced Healthcare Materials 出版者： Weinheim: WILEY-VCH Verlag 出版日期： 2013-10 出處： Advanced healthcare materials, 2013-10, Vol.2 (10), p.1322-1328 資源來源： Wiley Online Library Journals AutoHoldings 版權： Copyright © 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim 版權： Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 版權： Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 識別號： ISSN: 2192-2640 識別號： ISSN: 2192-2659 識別號： EISSN: 2192-2659 識別號： DOI: 10.1002/adhm.201300002 識別號： PMID: 23495239
Appears in Collections:	[Department of Biomedical Sciences and Engineering ] journal & Dissertation

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