Influence of Non-Alcoholic Fatty Liver Disease on Autonomic Changes Evaluated by the Time Domain, Frequency Domain, and Symbolic Dynamics of Heart Rate Variability

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Title:	Influence of Non-Alcoholic Fatty Liver Disease on Autonomic Changes Evaluated by the Time Domain, Frequency Domain, and Symbolic Dynamics of Heart Rate Variability
Authors:	林澂;Liu, Yu-Chen;Hung, Chi-Sheng;Wu, Yen-Wen;Lee, Yi-Chin;Lin, Yen-Hung;Lin, Chen;Lo, Men-Tzung;Chan, Chun-Chieh;Ma, Hsi-Pin;Ho, Yi-Lwun;Chen, Chien-Hung
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Adult;Age Factors;Arteriosclerosis;Atherosclerosis;Atherosclerosis - blood;Atherosclerosis - etiology;Atherosclerosis - physiopathology;Atherosclerosis - prevention & control;Biochemistry;Biology;Biomarkers;Body mass;Body Mass Index;Body size;Cardiac arrhythmia;Cardiovascular disease;Cardiovascular diseases;Diabetes Mellitus - blood;Diabetes Mellitus - diagnostic imaging;Diabetes Mellitus - physiopathology;Diagnosis;Dyslipidemia;Fatty liver;Fatty Liver - blood;Fatty Liver - complications;Fatty Liver - diagnostic imaging;Fatty Liver - physiopathology;Female;Glomerular Filtration Rate;Health risks;Heart Rate;Homeostasis;Humans;Hypertension;Hypertension - blood;Hypertension - complications;Hypertension - diagnostic imaging;Hypertension - physiopathology;Infrared radiation;Insulin;Insulin Resistance;Intervals;Leptin;Leptin - blood;Liver;Liver diseases;Male;Mathematics;Medical research;Medicine;Metabolic disorders;Metabolic syndrome;Metabolic Syndrome - blood;Metabolic Syndrome - complications;Metabolic Syndrome - diagnostic imaging;Metabolic Syndrome - physiopathology;Middle Aged;Non-alcoholic Fatty Liver Disease;Risk analysis;Risk Factors;Rodents;Sex Factors;Smoking;Time domain analysis;Type 2 diabetes;Ultrasonography;Ultrasound;Ultrasound imaging;Variability
Date:	2013-04-23
Issue Date:	2026-04-23 11:16:26 (UTC+8)
Publisher:	Public Library of Science;United States: Public Library of Science
Abstract:	摘要： Non-alcoholic fatty liver disease (NAFLD) is associated with cardiovascular atherosclerosis independent of classical risk factors. This study investigated the influence of NAFLD on autonomic changes, which is currently unknown. Subjects without an overt history of cardiovascular disease were enrolled during health checkups. The subjects diagnosed for NAFLD using ultrasonography underwent 5-min heart rate variability (HRV) measurements that was analyzed using the following indices: (1) the time domain with the standard deviation of N-N (SDNN) intervals and root mean square of successive differences between adjacent N-N intervals (rMSSD); (2) the frequency domain with low frequency (LF) and high frequency (HF) components; and (3) symbolic dynamics analysis. Routine blood biochemistry data and serum leptin levels were analyzed. Homeostasis model assessment of insulin resistance (HOMA-IR) was measured. Of the 497 subjects (mean age, 46.2 years), 176 (35.4%) had NAFLD. The HRV indices (Ln SDNN, Ln rMSSD, Ln LF, and Ln HF) were significantly decreased in the NAFLD group (3.51 vs 3.62 ms, 3.06 vs 3.22 ms, 5.26 vs 5.49 ms(2), 4.49 vs 5.21 ms(2), respectively, all P<0.05). Ln SDNN was significantly lower in the NAFLD group after adjustment for age, sex, hypertension, dyslipidemia, metabolic syndrome, body mass index, smoking, estimated glomerular filtration rate, HOMA-IR, and leptin (P<0.05). In the symbolic dynamic analysis, 0 V percentage was significantly higher in the NAFLD group (33.8% vs 28.7%, P = 0.001) and significantly correlated with linear HRV indices (Ln SDNN, Ln rMSSD, and Ln HF). NAFLD is associated with decreased Ln SDNN and increased 0 V percentage. The former association was independent of conventional cardiovascular risk factors and serum biomarkers (insulin resistance and leptin). Further risk stratification of autonomic dysfunction with falls or cardiovascular diseases by these HRV parameters is required in patients with NAFLD. 其他題名： PLoS One 出版者： United States: Public Library of Science 出版日期： 2013-04-23 出處： PloS one, 2013-04, Vol.8 (4), p.e61803 資源來源： Agricultural & Environmental Science Collection 版權： COPYRIGHT 2013 Public Library of Science 版權： 2013 Liu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 版權： 2013 Liu et al 2013 Liu et al 識別號： ISSN: 1932-6203 識別號： EISSN: 1932-6203 識別號： DOI: 10.1371/journal.pone.0061803 識別號： PMID: 23626730
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