Interleukin 10 promoter haplotype is associated with alcoholic liver cirrhosis in Taiwanese patients

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Title:	Interleukin 10 promoter haplotype is associated with alcoholic liver cirrhosis in Taiwanese patients
Authors:	王孫崇;Yang, An-Ming;Wen, Li-Li;Yang, Chang-Shyue;Wang, Sun-Chong;Chen, Chien-Sheng;Bair, Ming-Jong
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Alcoholic liver cirrhosis;Alcoholism;Analysis;Cytokines;Gene expression;Genes;Genetic aspects;Genetic Association Studies;Genetic polymorphisms;Genetic Predisposition to Disease;Genotype & phenotype;Haplotypes;Haplotypes - genetics;Hepatitis;Humans;IL 10 haplotype;IL 10 promoter polymorphism;Interleukin-10 - genetics;Interleukins;Internal Medicine;Liver cirrhosis;Liver Cirrhosis, Alcoholic - genetics;Liver diseases;Mutation;Original;Pancreatitis;Polymerase chain reaction;Polymorphism;Polymorphism, Single Nucleotide - genetics;Promoter Regions, Genetic;Taiwan;TNFα promoter polymorphism;Tumor necrosis factor;Ultrasonic imaging
Date:	2014-01-01
Issue Date:	2026-04-23 11:16:32 (UTC+8)
Publisher:	Elsevier (Singapore) Pte Ltd;China (Republic : 1949- ): Elsevier B.V
Abstract:	摘要： Alcoholic liver cirrhosis is a severe form of alcohol-related liver damage. More than 95% of heavy drinkers develop a fatty liver, but only 35% of them develop cirrhosis. We postulate that genetic factors may play a role in this difference. Genetic polymorphisms of the cytokine genes may influence Kupffer cells cytokine genes expression. In this study, we evaluated the promoter polymorphisms of interleukin (IL) 1β, IL 6, IL 10, and tumor necrosis factor alpha (TNFα) and aimed to clarify the association between the polymorphisms and the disease. Forty alcoholic patients with liver cirrhosis and 64 healthy volunteers were included in our investigation. Genotyping on IL 1β –511 T>C, IL 6 –572 G>C, IL 10 –819 C>T, IL 10 –1082 G>A, and TNFα –308 G>A was done. Another 36 patients with recurrent alcoholic pancreatitis were included as an additional control group. Genotyping on IL 10 –819 C>T and IL 10 –1082 G>A was done. The polymorphisms on IL 1 and IL 6 showed no significant association. The p value for TNFα –308 G>A was 0.028 in comparison with healthy volunteers. Although the p value was less than 0.05, it did not reach significance after Bonferroni correction. The p values for IL 10 –819 C>T and IL 10 –1082 G>A were respectively 0.031 and 0.026 in healthy volunteers and 0.028 and 0.023 in the alcoholic pancreatitis group. The results also did not reach significance after Bonferroni correction. Among the participants with the GCC haplotype, healthy volunteers had p = 0.027 (p < 0.05) and an odds ratio (OR) of 0.124 [confidence interval (95%) CI, 0.015–0.997], whereas the alcoholic pancreatitis group had p = 0.023 (p < 0.05) and an OR of 0.106 (95% CI, 0.012–0.912). The odds ratio of people having one ATA haplotype was 6.233 (95% CI, 0.739–52.547) in healthy volunteers and 6.588 (95% CI, 0.727–59.679) in the alcoholic pancreatitis group; the corresponding rate was 10.521 (95% CI, 1.252–88.440) and 12.833 (95% CI 1.408–117.008) for people with two ATA haplotypes. The p values in these groups were 0.031 (p < 0.05) and 0.028 (p < 0.05), respectively. The presence of a GCC haplotype could have protective effect against alcoholic liver disease, whereas the presence of an ATA haplotype could predispose carriers to the disease. The IL 10 promoter haplotype is associated with alcoholic liver cirrhosis in Taiwanese patients. 其他題名： Kaohsiung J Med Sci 出版者： China (Republic : 1949- ): Elsevier B.V 出版日期： 2014-06 出處： The Kaohsiung journal of medical sciences, 2014-06, Vol.30 (6), p.291-298 資源來源： ProQuest Open Access Content Collection 版權： 2014 版權： 2014 Kaohsiung Medical University 版權： Copyright © 2014. Published by Elsevier B.V. 版權： COPYRIGHT 2014 John Wiley & Sons, Inc. 版權： Copyright John Wiley & Sons, Inc. 2014 識別號： ISSN: 1607-551X 識別號： ISSN: 2410-8650 識別號： EISSN: 2410-8650 識別號： DOI: 10.1016/j.kjms.2014.02.016 識別號： PMID: 24835349
Appears in Collections:	[Department of Biomedical Sciences and Engineering ] journal & Dissertation

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