IsaB Inhibits Autophagic Flux to Promote Host Transmission of Methicillin-Resistant Staphylococcus aureus

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Title:	IsaB Inhibits Autophagic Flux to Promote Host Transmission of Methicillin-Resistant Staphylococcus aureus
Authors:	黃俊銘;Liu, Pei-Feng;Cheng, Jin-Shiung;Sy, Cheng-Len;Huang, Wei-Chun;Yang, Hsiu-Chen;Gallo, Richard L.;Huang, Chun-Ming;Shu, Chih-Wen
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Animals;Antigens, Bacterial - immunology;Autophagy - immunology;Cell Survival - immunology;Cross Infection - microbiology;Cross Infection - prevention & control;Disease Models, Animal;Female;Methicillin-Resistant Staphylococcus aureus - cytology;Methicillin-Resistant Staphylococcus aureus - immunology;Mice;Mice, Inbred ICR;Random Allocation;Sensitivity and Specificity;Staphylococcus aureus;Staphylococcus aureus - pathogenicity;Streptococcus;Virulence Factors
Date:	2015-11-01
Issue Date:	2026-04-23 11:16:35 (UTC+8)
Publisher:	Nature Publishing Group;United States: Elsevier Inc
Abstract:	摘要： Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a major nosocomial pathogen that is widespread in both health-care facilities and in the community at large, as a result of direct host-to-host transmission. Several virulence factors are associated with pathogen transmission to naive hosts. Immunodominant surface antigen B (IsaB) is a virulence factor that helps Staphylococcus aureus to evade the host defense system. However, the mechanism of IsaB on host transmissibility remains unclear. We found that IsaB expression was elevated in transmissible MRSA. Wild-type isaB strains inhibited autophagic flux to promote bacterial survival and elicit inflammation in THP-1 cells and mouse skin. MRSA isolates with increased IsaB expression showed decreased autophagic flux, and the MRSA isolate with the lowest IsaB expression showed increased autophagic flux. In addition, recombinant IsaB rescued the virulence of the isaB deletion strain and increased the group A streptococcus (GAS) virulence in vivo. Together, these results reveal that IsaB diminishes autophagic flux, thereby allowing MRSA to evade host degradation. These findings suggest that IsaB is a suitable target for preventing or treating MRSA infection. 其他題名： J Invest Dermatol 出版者： United States: Elsevier Inc 出版日期： 2015-11-01 出處： Journal of investigative dermatology, 2015-11, Vol.135 (11), p.2714-2722 資源來源： Alma/SFX Local Collection 版權： 2015 The Society for Investigative Dermatology, Inc 版權： Copyright Nature Publishing Group Nov 2015 識別號： ISSN: 0022-202X 識別號： ISSN: 1523-1747 識別號： EISSN: 1523-1747 識別號： DOI: 10.1038/jid.2015.254 識別號： PMID: 26134948
Appears in Collections:	[Department of Biomedical Sciences and Engineering ] journal & Dissertation

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