MAGIC-web: a platform for untargeted and targeted N-linked glycoprotein identification

NCUIR > college of Health Sciences and Technology > Department of Biomedical Sciences and Engineering > journal & Dissertation > Item 987654321/102798

Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/102798

Title:	MAGIC-web: a platform for untargeted and targeted N-linked glycoprotein identification
Authors:	張彙音;Lih, T. Mamie;Choong, Wai-Kok;Chen, Chen-Chun;Cheng, Cheng-Wei;Lin, Hsin-Nan;Chen, Ching-Tai;Chang, Hui-Yin;Hsu, Wen-Lian;Sung, Ting-Yi
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Computer Simulation;Databases, Protein;Glycopeptides - analysis;Glycopeptides - chemistry;Glycoproteins - analysis;Glycoproteins - chemistry;Humans;Internet;Mass Spectrometry;Polysaccharides - analysis;Polysaccharides - chemistry;Proteomics;Search Engine;Software;User-Computer Interface;Web Browser;Web Server issue
Date:	2016-07-08
Issue Date:	2026-04-23 11:16:58 (UTC+8)
Publisher:	Oxford University Press;England: Oxford University Press (OUP)
Abstract:	摘要： MAGIC-web is the first web server, to the best of our knowledge, that performs both untargeted and targeted analyses of mass spectrometry-based glycoproteomics data for site-specific N-linked glycoprotein identification. The first two modules, MAGIC and MAGIC+, are designed for untargeted and targeted analysis, respectively. MAGIC is implemented with our previously proposed novel Y1-ion pattern matching method, which adequately detects Y1- and Y0-ion without prior information of proteins and glycans, and then generates in silico MS(2) spectra that serve as input to a database search engine (e.g. Mascot) to search against a large-scale protein sequence database. On top of that, the newly implemented MAGIC+ allows users to determine glycopeptide sequences using their own protein sequence file. The third module, Reports Integrator, provides the service of combining protein identification results from Mascot and glycan-related information from MAGIC-web to generate a complete site-specific protein-glycan summary report. The last module, Glycan Search, is designed for the users who are interested in finding possible glycan structures with specific numbers and types of monosaccharides. The results from MAGIC, MAGIC+ and Reports Integrator can be downloaded via provided links whereas the annotated spectra and glycan structures can be visualized in the browser. MAGIC-web is accessible from http://ms.iis.sinica.edu.tw/MAGIC-web/index.html. 其他題名： Nucleic Acids Res 出版者： England: Oxford University Press (OUP) 出版日期： 2016-07-08 出處： Nucleic Acids Research, 2016-07, Vol.44 (W1), p.W575-580 版權： The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. 版權： The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. 2016 識別號： ISSN: 0305-1048 識別號： ISSN: 1362-4954 識別號： ISSN: 1362-4962 識別號： EISSN: 1362-4962 識別號： DOI: 10.1093/nar/gkw254 識別號： PMID: 27084943
Appears in Collections:	[Department of Biomedical Sciences and Engineering ] journal & Dissertation

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	24	View/Open

社群 sharing

Loading...