Multi-scale symbolic entropy analysis provides prognostic prediction in patients receiving extracorporeal life support

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Title:	Multi-scale symbolic entropy analysis provides prognostic prediction in patients receiving extracorporeal life support
Authors:	林澂;Lin, Yen-Hung;Huang, Hui-Chun;Chang, Yi-Chung;Lin, Chen;Lo, Men-Tzung;Liu, Li-Yu Daisy;Tsai, Pi-Ru;Chen, Yih-Sharng;Ko, Wen-Je;Ho, Yi-Lwun;Chen, Ming-Fong;Peng, Chung-Kang;Buchman, Timothy G
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Adult;Aged;Critical Care Medicine;Emergency Medicine;Entropy;Extracorporeal Circulation - methods;Extracorporeal Circulation - statistics & numerical data;Female;Heart Rate - physiology;Humans;Intensive;Life Support Systems - statistics & numerical data;Male;Medicine;Medicine & Public Health;Middle Aged;Predictive Value of Tests;Prognosis;Prospective Studies
Date:	2014-01-01
Issue Date:	2026-04-23 11:17:34 (UTC+8)
Publisher:	London: BioMed Central
Abstract:	摘要： Introduction Extracorporeal life support (ECLS) can temporarily support cardiopulmonary function, and is occasionally used in resuscitation. Multi-scale entropy (MSE) derived from heart rate variability (HRV) is a powerful tool in outcome prediction of patients with cardiovascular diseases. Multi-scale symbolic entropy analysis (MSsE), a new method derived from MSE, mitigates the effect of arrhythmia on analysis. The objective is to evaluate the prognostic value of MSsE in patients receiving ECLS. The primary outcome is death or urgent transplantation during the index admission. Methods Fifty-seven patients receiving ECLS less than 24 hours and 23 control subjects were enrolled. Digital 24-hour Holter electrocardiograms were recorded and three MSsE parameters (slope 5, Area 6–20, Area 6–40) associated with the multiscale correlation and complexity of heart beat fluctuation were calculated. Results Patients receiving ECLS had significantly lower value of slope 5, area 6 to 20, and area 6 to 40 than control subjects. During the follow-up period, 29 patients met primary outcome. Age, slope 5, Area 6 to 20, Area 6 to 40, acute physiology and chronic health evaluation II score, multiple organ dysfunction score (MODS), logistic organ dysfunction score (LODS), and myocardial infarction history were significantly associated with primary outcome. Slope 5 showed the greatest discriminatory power. In a net reclassification improvement model, slope 5 significantly improved the predictive power of LODS; Area 6 to 20 and Area 6 to 40 significantly improved the predictive power in MODS. In an integrated discrimination improvement model, slope 5 added significantly to the prediction power of each clinical parameter. Area 6 to 20 and Area 6 to 40 significantly improved the predictive power in sequential organ failure assessment. Conclusions MSsE provides additional prognostic information in patients receiving ECLS. 其他題名： Crit Care 出版者： London: BioMed Central 出版日期： 2014-10-24 出處： Critical care (London, England), 2014-10, Vol.18 (5), p.548, Article 548 資源來源： Springer Nature OA Free Journals 版權： Lin et al.; licensee BioMed Central Ltd. 2014 版權： COPYRIGHT 2014 BioMed Central Ltd. 識別號： ISSN: 1364-8535 識別號： ISSN: 1466-609X 識別號： EISSN: 1364-8535 識別號： EISSN: 1466-609X 識別號： DOI: 10.1186/s13054-014-0548-3 識別號： PMID: 25341381
Appears in Collections:	[Department of Biomedical Sciences and Engineering ] journal & Dissertation

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