Negative association between serum parathyroid hormone levels and urinary perchlorate, nitrate, and thiocyanate concentrations in U.S. adults: The national health and nutrition examination survey 2005-2006

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Title:	Negative association between serum parathyroid hormone levels and urinary perchlorate, nitrate, and thiocyanate concentrations in U.S. adults: The national health and nutrition examination survey 2005-2006
Authors:	許藝瓊;Ko, Wen-Ching;Liu, Chien-Liang;Lee, Jie-Jen;Liu, Tsang-Pai;Yang, Po-Sheng;Hsu, Yi-Chiung;Cheng, Shih-Ping
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Adult;Adults;Chromatography, Ion Exchange;Community colleges;Confidence intervals;Creatinine;Cross-Sectional Studies;Data processing;Drinking water;Female;Health surveys;Hospitals;Humans;Hyperparathyroidism;Hypertension;Iodides;Logistic Models;Male;Medicine;Medicine and Health Sciences;Nitrates;Nitrates - urine;Nursing;Nutrition;Nutrition research;Nutrition Surveys;Parathyroid;Parathyroid hormone;Parathyroid Hormone - blood;Parathyroid hormones;Perchlorate;Perchlorates - urine;Perchloric acid;Pharmacology;Sensitivity analysis;Smoking;Sodium;Studies;Surgery;Symporters - antagonists & inhibitors;Thiocyanates - urine;Thyroid;Thyroid cancer;United States;Urine;Vitamin D
Date:	2014-12-16
Issue Date:	2026-04-23 11:17:41 (UTC+8)
Publisher:	Public Library of Science;United States: Public Library of Science
Abstract:	摘要： Perchlorate, nitrate, and thiocyanate are well-known inhibitors of the sodium-iodide symporter and may disrupt thyroid function. This exploratory study investigated the association among urinary perchlorate, nitrate, and thiocyanate concentrations and parathyroid hormone (PTH) levels in the general U.S. population. We analyzed data on 4265 adults (aged 20 years and older) from the National Health and Nutrition Examination Survey in 2005 through 2006 to evaluate the relationship among urinary perchlorate, nitrate, and thiocyanate concentration and PTH levels and the presence of hyperparathyroidism cross-sectionally. The geometric means and 95% confidence interval (95% CI) concentrations of urinary perchlorate, nitrate, and thiocyanate were 3.38 (3.15-3.62), 40363 (37512-43431), and 1129 (1029-1239) ng/mL, respectively. After adjusting for confounding variables and sample weights, creatinine-corrected urinary perchlorate was negatively associated with serum PTH levels in women (P = 0.001), and creatinine-corrected urinary nitrate and thiocyanate were negatively associated with serum PTH levels in both sex groups (P = 0.001 and P<0.001 for men, P = 0.018 and P<0.001 for women, respectively). Similar results were obtained from sensitivity analyses performed for exposure variables unadjusted for creatinine with urinary creatinine added as a separate covariate. There was a negative relationship between hyperparathyroidism and urinary nitrate and thiocyanate [odds ratio (95% CI) = 0.77 (0.60-0.98) and 0.69 (0.61-0.79), respectively]. A higher urinary concentration of perchlorate, nitrate, and thiocyanate is associated with lower serum PTH levels. Future studies are needed to determine the pathophysiological background of the observation. 其他題名： PLoS One 出版者： United States: Public Library of Science 出版日期： 2014-12-16 出處： PloS one, 2014-12, Vol.9 (12), p.e115245 資源來源： ProQuest 版權： COPYRIGHT 2014 Public Library of Science 版權： 2014 Ko et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 版權： 2014 Ko et al 2014 Ko et al 識別號： ISSN: 1932-6203 識別號： EISSN: 1932-6203 識別號： DOI: 10.1371/journal.pone.0115245 識別號： PMID: 25514572
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