Neuronal correlates of a virtual-reality-based passive sensory P300 network

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Title:	Neuronal correlates of a virtual-reality-based passive sensory P300 network
Authors:	陳純娟;Chen, Chun-Chuan;Syue, Kai-Syun;Li, Kai-Chiun;Yeh, Shih-Ching
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Active control;Adult;Alternations;Auditory evoked potentials;Biology and Life Sciences;Biomedical engineering;Brain;Brain - physiology;Computer applications;Computer Simulation;Engineering;Event-related potentials;Event-Related Potentials, P300;Human-computer interface;Humans;Implants;Latency;Male;Medicine and Health Sciences;Models, Neurological;Modulation;Neural networks;Neurons;Patients;Scalp;Studies;Virtual reality;Young Adult
Date:	2014-11-17
Issue Date:	2026-04-23 11:17:44 (UTC+8)
Publisher:	Public Library of Science;United States: Public Library of Science
Abstract:	摘要： P300, a positive event-related potential (ERP) evoked at around 300 ms after stimulus, can be elicited using an active or passive oddball paradigm. Active P300 requires a person's intentional response, whereas passive P300 does not require an intentional response. Passive P300 has been used in incommunicative patients for consciousness detection and brain computer interface. Active and passive P300 differ in amplitude, but not in latency or scalp distribution. However, no study has addressed the mechanism underlying the production of passive P300. In particular, it remains unclear whether the passive P300 shares an identical active P300 generating network architecture when no response is required. This study aims to explore the hierarchical network of passive sensory P300 production using dynamic causal modelling (DCM) for ERP and a novel virtual reality (VR)-based passive oddball paradigm. Moreover, we investigated the causal relationship of this passive P300 network and the changes in connection strength to address the possible functional roles. A classical ERP analysis was performed to verify that the proposed VR-based game can reliably elicit passive P300. The DCM results suggested that the passive and active P300 share the same parietal-frontal neural network for attentional control and, underlying the passive network, the feed-forward modulation is stronger than the feed-back one. The functional role of this forward modulation may indicate the delivery of sensory information, automatic detection of differences, and stimulus-driven attentional processes involved in performing this passive task. To our best knowledge, this is the first study to address the passive P300 network. The results of this study may provide a reference for future clinical studies on addressing the network alternations under pathological states of incommunicative patients. However, caution is required when comparing patients' analytic results with this study. For example, the task presented here is not applicable to incommunicative patients. 其他題名： PLoS One 出版者： United States: Public Library of Science 出版日期： 2014-11-17 出處： PloS one, 2014-11, Vol.9 (11), p.e112228 資源來源： Agricultural & Environmental Science Collection 版權： COPYRIGHT 2014 Public Library of Science 版權： 2014 Chen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 版權： 2014 Chen et al 2014 Chen et al 識別號： ISSN: 1932-6203 識別號： EISSN: 1932-6203 識別號： DOI: 10.1371/journal.pone.0112228 識別號： PMID: 25401520
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