Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice

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Title:	Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice
Authors:	馬念涵;Chiou, Yi-Shiou;Ma, Nianhan Jia-Lin;Sang, Shengmin;Ho, Chi-Tang;Wang, Ying-Jan;Pan, Min-Hsiung
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Acetates - administration & dosage;Acetylation;Animals;anti-inflammatory activity;Biological and medical sciences;carcinogenesis;Catechin - administration & dosage;Catechin - analogs & derivatives;Cell Transformation, Neoplastic - genetics;Cell Transformation, Neoplastic - metabolism;chemoprevention;colitis;Colitis - drug therapy;Colitis - genetics;Colitis - metabolism;Colitis - prevention & control;colon;Colonic Neoplasms - drug therapy;Colonic Neoplasms - genetics;Colonic Neoplasms - metabolism;Colonic Neoplasms - prevention & control;colorectal neoplasms;dextran;Dextran Sulfate - adverse effects;Down-Regulation - drug effects;Food industries;Fundamental and applied biological sciences. Psychology;Gene Expression - drug effects;heme oxygenase (biliverdin-producing);heme oxygenase (decyclizing);Humans;Male;Mice;Mice, Inbred ICR;mitogen-activated protein kinase;phosphorylation;Premedication;Signal Transduction - drug effects;sodium sulfate
Date:	2012-04-04
Issue Date:	2026-04-23 11:18:42 (UTC+8)
Publisher:	American Chemical Society;Washington, DC: American Chemical Society
Abstract:	摘要： Previous studies reported that peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) has antiproliferative and anti-inflammatory activities. Here, we evaluated the chemopreventive effects and underlying molecular mechanisms of dietary administration of AcEGCG and EGCG in dextran sulfate sodium (DSS)-induced colitis in mice. The mice were fed a diet supplemented with either AcEGCG or EGCG prior to DSS induction. Our results indicated that AcEGCG administration was more effective than EGCG in preventing the shortening of colon length and the formation of aberrant crypt foci (ACF) and lymphoid nodules (LN) in mouse colon stimulated by DSS. Our study observes that AcEGCG treatment inhibited histone 3 lysine 9 (H3K9) acetylation but did not affect histone acetyltransferase (HAT) activity and acetyl- CREB-binding protein (CBP)/p300 levels. In addition, pretreatment with AcEGCG decreased the proinflammatory mediator levels by down-regulating of PI3K/Akt/NFκB phosphorylation and p65 acetylation. We also found that treatment with AcEGCG increased heme oxygenase-1(HO-1) expression via activation of extracellular signal-regulated protein kinase (ERK)1/2 signaling and acetylation of NF-E2-related factor 2 (Nrf2), thereby abating DSS-induced colitis. Moreover, dietary feeding with AcEGCG markedly reduced colitis-driven colon cancer in mice. Taken together, these results demonstrated for the first time the in vivo chemopreventive efficacy and molecular mechanisms of dietary AcEGCG against inflammatory bowel disease (IBD) and potentially colon cancer associated with colitis. These findings provide insight into the biological actions of AcEGCG and might establish a molecular basis for the development of new cancer chemopreventive agents. 其他題名： J. Agric. Food Chem 出版者： Washington, DC: American Chemical Society 出版日期： 2012-04-04 出處： Journal of Agricultural and Food Chemistry, 2012-04, Vol.60 (13), p.3441-3451 資源來源： American Chemical Society (ACS) - Revues 版權： Copyright © 2012 American Chemical Society 版權： 2015 INIST-CNRS 識別號： ISSN: 0021-8561 識別號： ISSN: 1520-5118 識別號： EISSN: 1520-5118 識別號： DOI: 10.1021/jf300441p 識別號： PMID: 22409325 識別號： CODEN: JAFCAU
Appears in Collections:	[Department of Biomedical Sciences and Engineering ] journal & Dissertation

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