摘要： Curcumin has been extensively studied for its therapeutic effects in a variety of disorders. Fermented soy consumption is associated with a low incidence rate of chronic diseases in many Asian countries. The aim of this study was to investigate the potential underlying mechanisms of the effect of a phyto-power dietary supplement on liver fibrosis. Sprague-Dawley rats were intraperitoneally injected with dimethylnitrosamine (DMN; 10 mg kg −1 ) three times a week for four consecutive weeks. A phyto-power dietary supplement (50 or 100 mg kg −1 ) was administered by oral gavage daily for four weeks. Liver morphology, function, and fibrotic status were examined in DMN induced hepatic fibrogenesis. However, a phyto-power dietary supplement alleviated liver damage as indicated by histopathological examination of the α-smooth muscle actin (α-SMA) and collagen I, accompanied by the concomitant reduction of transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase 2 (MMP2). These data indicate that the phyto-power dietary supplement may inhibit the TGF-β1/Smad signaling and relieve liver damage in experimental fibrosis. Phyto-power dietary supplement (SC) reduces collagen deposition in dimethylnitrosamine (DMN)-treated animals. 其他題名： Food Funct 出版者： England 出版日期： 2013-02-26 出處： Food & function, 2013-02, Vol.4 (3), p.47-475 識別號： ISSN: 2042-6496 識別號： ISSN: 2042-650X 識別號： EISSN: 2042-650X 識別號： DOI: 10.1039/c2fo30306j 識別號： PMID: 23291610
