Bentham Science Publishers B.V.;United Arab Emirates: Bentham Science Publishers Ltd
摘要:
摘要： Propionibacterium acnes (P. acnes), a Gram-positive anaerobic bacterium, is a commensal organism in human skin. Like human cells, the bacteria produce porphyrins, which exhibit fluorescence properties and make bacteria visible with a Wood's lamp. In this review, we compare the porphyrin biosynthesis in humans and P. acnes. Also, since P. acnes living on the surface of skin receive the same radiation exposure as humans, we envision that the changes in porphyrin profiles (the absorption spectra and/or metabolism) of P. acnes by radiation may mirror the response of human cells to radiation. The porphyrin profiles of P. acnes may be a more accurate reflection of radiation risk to the patient than other biodosimeters/biomarkers such as gene up-/down-regulation, which may be non-specific due to patient related factors such as autoimmune diseases. Lastly, we discuss the challenges and possible solutions for using the P. acnes response to predict the radiation risk. 其他題名： CMC 出版者： United Arab Emirates: Bentham Science Publishers Ltd 出版日期： 2013-02-01 出處： Current medicinal chemistry, 2013-02, Vol.20 (4), p.562-568 版權： 2013 Bentham Science Publishers 2013 識別號： ISSN: 0929-8673 識別號： EISSN: 1875-533X 識別號： DOI: 10.2174/092986713804910085 識別號： PMID: 23231351
