Prescriptions of traditional Chinese medicine are specific to cancer types and adjustable to temperature changes

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Title:	Prescriptions of traditional Chinese medicine are specific to cancer types and adjustable to temperature changes
Authors:	王孫崇;Chiu, Pei-Hsun;Hsieh, Hsin-Ying;Wang, Sun-Chong
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Antineoplastic Combined Chemotherapy Protocols;Biology;Cancer;Carcinogenesis;Carcinogens;Chemotherapy;Chinese medicine;Computer Science;Databases, Factual;Development and progression;DNA methylation;Drug delivery;Drug development;Drug Prescriptions - statistics & numerical data;Drugs;Environmental changes;Environmental factors;Epigenetics;Health care;Herbal medicine;Herbs;Humans;Inflammation;Lung cancer;Lung diseases;Malignancy;Medical diagnosis;Medicine;Medicine, Chinese Traditional - methods;Molecular Targeted Therapy;Morbidity;National health insurance;Neoplasms;Neoplasms - drug therapy;Patients;Pharmacogenomics;Precision medicine;Radiation;Seasons;Side effects;Taiwan;Temperature;Temperature changes;Traditional Chinese medicine
Date:	2012-02-16
Issue Date:	2026-04-23 11:18:49 (UTC+8)
Publisher:	Public Library of Science;United States: Public Library of Science
Abstract:	摘要： Targeted cancer therapies, with specific molecular targets, ameliorate the side effect issue of radiation and chemotherapy and also point to the development of personalized medicine. Combination of drugs targeting multiple pathways of carcinogenesis is potentially more fruitful. Traditional Chinese medicine (TCM) has been tailoring herbal mixtures for individualized healthcare for two thousand years. A systematic study of the patterns of TCM formulas and herbs prescribed to cancers is valuable. We analysed a total of 187,230 TCM prescriptions to 30 types of cancer in Taiwan in 2007, a year's worth of collection from the National Health Insurance reimbursement database (Taiwan). We found that a TCM cancer prescription consists on average of two formulas and four herbs. We show that the percentage weights of TCM formulas and herbs in a TCM prescription follow Zipf's law with an exponent around 0.6. TCM prescriptions to benign neoplasms have a larger Zipf's exponent than those to malignant cancers. Furthermore, we show that TCM prescriptions, via weighted combination of formulas and herbs, are specific to not only the malignancy of neoplasms but also the sites of origins of malignant cancers. From the effects of formulas and natures of herbs that were heavily prescribed to cancers, that cancers are a 'warm and stagnant' syndrome in TCM can be proposed, suggesting anti-inflammatory regimens for better prevention and treatment of cancers. We show that TCM incorporated relevant formulas to the prescriptions to cancer patients with a secondary morbidity. We compared TCM prescriptions made in different seasons and identified temperatures as the environmental factor that correlates with changes in TCM prescriptions in Taiwan. Lung cancer patients were among the patients whose prescriptions were adjusted when temperatures drop. The findings of our study provide insight to TCM cancer treatment, helping dialogue between modern western medicine and TCM for better cancer care. 其他題名： PLoS One 出版者： United States: Public Library of Science 出版日期： 2012-02-16 出處： PloS one, 2012-02, Vol.7 (2), p.e31648 資源來源： ProQuest SciTech Premium Collection Natural Science Collection Agricultural & Environmental Science Collection 版權： COPYRIGHT 2012 Public Library of Science 版權： 2012 Chiu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 版權： Chiu et al. 2012 識別號： ISSN: 1932-6203 識別號： EISSN: 1932-6203 識別號： DOI: 10.1371/journal.pone.0031648 識別號： PMID: 22359613
Appears in Collections:	[Department of Biomedical Sciences and Engineering ] journal & Dissertation

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