Probing the fractal pattern of heartbeats in drosophila pupae by visible optical recording system

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題名:	Probing the fractal pattern of heartbeats in drosophila pupae by visible optical recording system
作者:	羅孟宗;Lin, Chen;Chang, Yi-Chung;Cheng, Ya-Chen;Lai, Po-Jung;Yeh, Chien-Hung;Hsieh, Wan-Hsin;Hu, Kun;Wu, June-Tai;Lee, Hsiu-Hsiang;Lo, Men-Tzung;Ho, Yi-Lwun
貢獻者:	生醫理工學院生醫科學與工程學系
關鍵詞:	631/1647/245/2225;631/1647/245/2226;Adenosine triphosphatase;Animals;Ca2+-transporting ATPase;Calcium (intracellular);Calcium (reticular);Calcium - metabolism;Cardiovascular system;Drosophila - growth & development;Drosophila - physiology;Endoplasmic reticulum;Endoplasmic Reticulum - metabolism;Fractals;Heart;Heart Rate;Humanities and Social Sciences;Insects;Irradiation;Larva - physiology;Light effects;multidisciplinary;Optical Devices;Principal Component Analysis;Principal components analysis;Radiation;Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism;Scaling;Science
日期:	2016-08-18
上傳時間:	2026-04-23 11:19:27 (UTC+8)
出版者:	Nature Publishing Group;London: Nature Publishing Group UK
摘要:	摘要： Judiciously tuning heart rates is critical for regular cardiovascular function. The fractal pattern of heartbeats — a multiscale regulation in instantaneous fluctuations — is well known for vertebrates. The most primitive heart system of the Drosophila provides a useful model to understand the evolutional origin of such a fractal pattern as well as the alterations of fractal pattern during diseased statuses. We developed a non-invasive visible optical heart rate recording system especially suitable for long-term recording by using principal component analysis (PCA) instead of fluorescence recording system to avoid the confounding effect from intense light irradiation. To deplete intracellular Ca 2+ levels, the expression of sarco-endoplasmic reticulum Ca 2+ -ATPase (SERCA) was tissue-specifically knocked down. The SERCA group shows longer heart beat intervals (Mean ± SD: 1009.7 ± 151.6 ms) as compared to the control group (545.5 ± 45.4 ms, p < 0.001). The multiscale correlation of SERCA group (scaling exponent: 0.77 ± 0.07), on the other hand, is weaker than that of the control Drosophila (scaling exponent: 0.85 ± 0.03) (p = 0.016). 其他題名： Sci Rep 出版者： London: Nature Publishing Group UK 出版日期： 2016-08-18 出處： Scientific reports, 2016-08, Vol.6 (1), p.31950, Article 31950 資源來源： Publicly Available Content Database 版權： The Author(s) 2016 版權： Copyright Nature Publishing Group Aug 2016 版權： Copyright © 2016, The Author(s) 2016 The Author(s) 識別號： ISSN: 2045-2322 識別號： EISSN: 2045-2322 識別號： DOI: 10.1038/srep31950 識別號： PMID: 27535299
顯示於類別:	[生醫科學與工程學系] 期刊論文

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