Prognostic significance of adipocytokines in systolic heart failure patients

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Title:	Prognostic significance of adipocytokines in systolic heart failure patients
Authors:	羅孟宗;Wu, Xue-Ming;Lin, Yen-Hung;Chen, Aaron;Hsu, Tse-Pin;Wu, Yen-Wen;Lin, Hung-Ju;Hsu, Ron-Bin;Lee, Chi-Ming;Wang, Shoei-Shen;Lo, Men-Tzung;Ho, Yi-Lwun;Chen, Ming-Fong
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Adipocytokine;Adipokines - blood;adiponectin;Biological and medical sciences;Biomarkers - blood;Cardiology. Vascular system;Chronic Disease;Female;General aspects;Heart;heart failure;Heart failure, cardiogenic pulmonary edema, cardiac enlargement;Heart Failure, Systolic - blood;Heart Failure, Systolic - etiology;Heart Failure, Systolic - mortality;Humans;Kaplan-Meier Estimate;leptin;Male;Medical sciences;Middle Aged;Prognosis;resistin;Risk Factors;Ventricular Dysfunction, Left - blood;Ventricular Dysfunction, Left - complications;Ventricular Dysfunction, Left - mortality;visfatin
Date:	2012-10-01
Issue Date:	2026-04-23 11:19:30 (UTC+8)
Publisher:	Wiley-Blackwell Publishing Ltd;Oxford, UK: Blackwell Publishing Ltd
Abstract:	摘要： Eur J Clin Invest 2012; 42 (10): 1079–1086 Objectives The goal of this study was designed to assess prognostic values of simultaneous measurement of adipocytokines in systolic heart failure (HF) patients. Methods Patients with HF manifestations and left ventricular ejection fraction (LVEF) ≤ 50% were selected in this study. Gender, age, medications and serum biochemical data were recorded upon admissions. Adipocytokines including adiponectin, leptin, resistin, visfatin and retinol binding protein‐4 were measured. Results A total of 108 (83 males and 25 females) patients were enroled. The age was 62 ± 15 years and mean LVEF was 35%. Twenty patients died during 776 ± 323 days follow‐up. In univariate analysis, mortality was found to be associated with the log‐transformed values of serum resistin (β = 5·616, P = 0·04), log‐transformed values of serum adiponectin (β = 4·377, P = 0·038), age (β = 1·071, P < 0·001), NTHA functional status (β = 3·752, P = 0·001) and body mass index (β = 0·858, P = 0·012). Patients with higher level of serum resistin were associated with higher mortality (P = 0·012). In multivariate analysis, mortality is associated with log‐transformed values of serum resistin (β = 3·666, P = 0·045), age (β = 1·044, P = 0·017) and NTHA functional status (β = 2·541, P = 0·025). Conclusions Serum resistin level was associated with higher mortality in systolic HF patients even after adjusting clinical parameters. Resistin may be an informative risk marker for systolic HF patients. 其他題名： Eur J Clin Invest 出版者： Oxford, UK: Blackwell Publishing Ltd 出版日期： 2012-10 出處： European journal of clinical investigation, 2012-10, Vol.42 (10), p.1079-1086 資源來源： Wiley Online Library - AutoHoldings Journals 版權： 2012 The Authors. European Journal of Clinical Investigation © 2012 Stichting European Society for Clinical Investigation Journal Foundation 版權： 2015 INIST-CNRS 版權： 2012 The Authors. European Journal of Clinical Investigation © 2012 Stichting European Society for Clinical Investigation Journal Foundation. 識別號： ISSN: 0014-2972 識別號： ISSN: 1365-2362 識別號： EISSN: 1365-2362 識別號： DOI: 10.1111/j.1365-2362.2012.02698.x 識別號： PMID: 22712474
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