Progress on Nme (NDP kinase/Nm23/awd) gene family-related functions derived from animal model systems: Studies on development, cardiovascular disease, and cancer metastasis exemplified

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题名:	Progress on Nme (NDP kinase/Nm23/awd) gene family-related functions derived from animal model systems: Studies on development, cardiovascular disease, and cancer metastasis exemplified
作者:	徐沺;Hsu, Tien;Steeg, Patricia S.;Zollo, Massimo;Wieland, Thomas
贡献者:	生醫理工學院生醫科學與工程學系
关键词:	Animals;Biomedical and Life Sciences;Biomedicine;Cardiovascular Diseases - genetics;Cardiovascular Diseases - metabolism;Editorial;Humans;Models, Animal;Neoplasms - drug therapy;Neoplasms - genetics;Neoplasms - metabolism;Neoplasms - pathology;Neurosciences;Nucleoside-Diphosphate Kinase - genetics;Nucleoside-Diphosphate Kinase - metabolism;Pharmacology/Toxicology
日期:	2015-01-01
上传时间:	2026-04-23 11:19:32 (UTC+8)
出版者:	Springer Verlag;Berlin/Heidelberg: Springer Berlin Heidelberg
摘要:	摘要： The enzyme nucleoside diphosphate kinase (NDP kinase or NDPK) was discovered in the 1950s as biochemical activity that removes the terminal phosphate from a nucleoside triphosphate (NTP) and adds it to a nucleoside diphosphate (NDP). Thus, the correct biochemical name for the enzyme is NTP/NDP transphosphorylase, and it is generally regarded as a housekeeping enzyme required for nucleotide homeostasis. At least four of the ten Nme gene family products (Nme1-Nme4), also called group I Nme proteins, carry that enzymatic activity. A far more complex story was started in the 1990s when it became evident that enhanced cancer metastasis was linked to reduced expression of a gene named nm23, which turned out to be identical to human Nme1 = NDPK A. To date, the function of Nme1 underlying its metastasis suppressor activity has not been clarified. It is hoped that fundamental cellular and molecular insights into the role of NDP kinase/Nm23/awd proteins in development may explain its pathophysio ... 其他題名： Naunyn-Schmiedeberg's Arch Pharmacol 其他題名： Naunyn Schmiedebergs Arch Pharmacol 出版者： Berlin/Heidelberg: Springer Berlin Heidelberg 出版日期： 2015-02-01 出處： Naunyn-Schmiedeberg's archives of pharmacology, 2015-02, Vol.388 (2), p.109-117 版權： Springer-Verlag Berlin Heidelberg (outside the USA) 2015 識別號： ISSN: 0028-1298 識別號： ISSN: 1432-1912 識別號： EISSN: 1432-1912 識別號： DOI: 10.1007/s00210-014-1079-9 識別號： PMID: 25585611
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