Propionibacterium acnes in the pathogenesis and immunotherapy of acne vulgaris

NCUIR > college of Health Sciences and Technology > Department of Biomedical Sciences and Engineering > journal & Dissertation > Item 987654321/102897

Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/102897

Title:	Propionibacterium acnes in the pathogenesis and immunotherapy of acne vulgaris
Authors:	黃俊銘;Liu, Pei-Feng;Hsieh, Yao-Dung;Lin, Ya-Ching;Two, Aimee;Shu, Chih-Wen;Huang, Chun-Ming
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Acne Vulgaris - immunology;Acne Vulgaris - therapy;Animals;Bacterial Vaccines - therapeutic use;Corynebacterium;Humans;Immunotherapy;Propionibacterium acnes
Date:	2015-09-01
Issue Date:	2026-04-23 11:19:34 (UTC+8)
Publisher:	Bentham Science Publishers B.V.;Netherlands: Bentham Science Publishers Ltd
Abstract:	摘要： Acne vulgaris, a multi-factorial disease, is one of the most common skin diseases, affecting an estimated 80% of Americans at some point during their lives. The gram-positive and anaerobic Propionibacterium acnes ( P. acnes ) bacterium has been implicated in acne inflammation and pathogenesis. Therapies for acne vulgaris using antibiotics generally lack bacterial specificity, promote the generation of antibiotic-resistant bacterial strains, and cause adverse effects. Immunotherapy against P. acnes or its antigens (sialidase and CAMP factor) has been demonstrated to be effective in mice, attenuating P. acnes -induced inflammation; thus, this method may be applied to develop a potential vaccine targeting P. acnes for acne vulgaris treatment. This review summarizes reports describing the role of P. acnes in the pathogenesis of acne and various immunotherapy-based approaches targeting P. acnes, suggesting the potential effectiveness of immunotherapy for acne vulgaris as well as P. acnes -associated diseases. 其他題名： CDM 出版者： Netherlands: Bentham Science Publishers Ltd 出版日期： 2015-01-01 出處： Current Drug Metabolism, 2015-01, Vol.16 (4), p.245-254 識別號： ISSN: 1389-2002 識別號： ISSN: 1875-5453 識別號： EISSN: 1875-5453 識別號： DOI: 10.2174/1389200216666150812124801 識別號： PMID: 26264195
Appears in Collections:	[Department of Biomedical Sciences and Engineering ] journal & Dissertation

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	31	View/Open

社群 sharing

Loading...