Quality of Life after Surgery or Surveillance for Asymptomatic Primary Hyperparathyroidism: A Meta-Analysis of Randomized Controlled Trials

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Title:	Quality of Life after Surgery or Surveillance for Asymptomatic Primary Hyperparathyroidism: A Meta-Analysis of Randomized Controlled Trials
Authors:	許藝瓊;Cheng, Shih-Ping;Lee, Jie-Jen;Liu, Tsang-Pai;Yang, Po-Sheng;Liu, Sung-Chen;Hsu, Yi-Chiung;Liu, Chien-Liang
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Humans;Hyperparathyroidism, Primary - surgery;Hyperparathyroidism, Primary - therapy;Quality of Life;Randomized Controlled Trials as Topic;Systematic Review and Meta-Analysis;Watchful Waiting
Date:	2015-01-01
Issue Date:	2026-04-23 11:19:43 (UTC+8)
Publisher:	Lippincott Williams and Wilkins Ltd.;United States: Wolters Kluwer Health, Inc. All rights reserved
Abstract:	摘要： A number of studies have investigated the effects of surgery on symptoms and quality of life in patients with hyperparathyroidism. However, the results are inconsistent. We conducted this meta-analysis to quantitatively assess changes in quality of life among patients with asymptomatic primary hyperparathyroidism. Different databases were searched for randomized controlled trials comparing surgery with surveillance. Quality of life was measured by the Short Form-36 general health survey. The pooled random-effects estimates of standardized mean difference (SMD) and 95% confidence intervals (CIs) were calculated. Three trials involving 294 participants were included. At 1 year, patients undergoing parathyroidectomy had significantly better physical role functioning (SMD, 0.31; 95% CI 0.04-0.57; P = 0.02) and emotional role functioning (SMD, 0.29; 95% CI 0.02-0.55; P = 0.03). At 2 years, the surgery group had significantly better emotional role functioning (SMD, 0.35; 95% CI 0.02-0.67; P = 0.04) than the surveillance group. Furthermore, compared with baseline, emotional role functioning improved after surgery (SMD, 0.31; 95% CI 0.02-0.60; P = 0.04), whereas emotional role functioning tended to get worse in patients assigned to medical surveillance (SMD, -0.27; 95% CI -0.55 to 0.02; P = 0.07). Although Short Form-36 is a generic instrument, our results suggest that parathyroidectomy may be associated with better quality of life, especially in the emotional aspects of well-being. 其他題名： Medicine (Baltimore) 出版者： United States: Wolters Kluwer Health, Inc. All rights reserved 出版日期： 2015-06-01 出處： Medicine (Baltimore), 2015-06, Vol.94 (23), p.e931-e931 版權： Wolters Kluwer Health, Inc. All rights reserved. 版權： Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. 2015 識別號： ISSN: 0025-7974 識別號： EISSN: 1536-5964 識別號： DOI: 10.1097/MD.0000000000000931 識別號： PMID: 26061318
Appears in Collections:	[Department of Biomedical Sciences and Engineering ] journal & Dissertation

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