Rapid identification of health care-associated infections with an integrated fluorescence anisotropy system

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题名:	Rapid identification of health care-associated infections with an integrated fluorescence anisotropy system
作者:	黃貞翰;Park, Ki Soo;Huang, Chen-Han;Lee, Kyungheon;Yoo, Yeong-Eun;Castro, Cesar M.;Weissleder, Ralph;Lee, Hakho
贡献者:	生醫理工學院生醫科學與工程學系
关键词:	Bacteria - isolation & purification;Bacteria - pathogenicity;Biotechnology;Catheter-Related Infections - diagnosis;Catheter-Related Infections - microbiology;Cross Infection - diagnosis;Cross Infection - microbiology;Drug Resistance, Microbial - genetics;Fluorescence Polarization - methods;Humans;SciAdv r-articles
日期:	2016-05-01
上传时间:	2026-04-23 11:19:58 (UTC+8)
出版者:	American Association for the Advancement of Science;United States: American Association for the Advancement of Science
摘要:	摘要： A portable system for rapid bacterial profiling aims to rapidly diagnose health care–associated infections. Health care–associated infections (HAIs) and drug-resistant pathogens have become a major health care issue with millions of reported cases every year. Advanced diagnostics would allow clinicians to more quickly determine the most effective treatment, reduce the nonspecific use of broad-spectrum antimicrobials, and facilitate enrollment in new antibiotic treatments. We present a new integrated system, polarization anisotropy diagnostics (PAD), for rapid detection of HAI pathogens. The PAD uses changes of fluorescence anisotropy when detection probes recognize target bacterial nucleic acids. The technology is inherently robust against environmental noise and economically scalable for parallel measurements. The assay is fast (2 hours) and performed on-site in a single-tube format. When applied to clinical samples obtained from interventional procedures, the PAD determined the overall bacterial burden, differentiated HAI bacterial species, and identified drug resistance and virulence status. The PAD system holds promise as a powerful tool for near-patient, rapid HAI testing. 其他題名： Sci Adv 出版者： United States: American Association for the Advancement of Science 出版日期： 2016-05-01 出處： Science advances, 2016-05, Vol.2 (5), p.e1600300 版權： Copyright © 2016, The Authors 2016 The Authors 識別號： ISSN: 2375-2548 識別號： EISSN: 2375-2548 識別號： DOI: 10.1126/sciadv.1600300 識別號： PMID: 28861468
显示于类别:	[生醫科學與工程學系] 期刊論文

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