Regulation of leptin receptor expression in human papillary thyroid cancer cells

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Title:	Regulation of leptin receptor expression in human papillary thyroid cancer cells
Authors:	許藝瓊;Cheng, Shih-Ping;Liu, Chien-Liang;Hsu, Yi-Chiung;Chang, Yuan-Ching;Huang, Shih-Yuan;Lee, Jie-Jen
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Blotting, Western;Carcinoma - genetics;Carcinoma - metabolism;Carcinoma, Papillary;Cell Hypoxia;Cell Line, Tumor;DNA Methylation - drug effects;DNA Modification Methylases - antagonists & inhibitors;DNA, Neoplasm - metabolism;Down-Regulation - drug effects;Enzyme Inhibitors - pharmacology;Epigenetic regulation;Gene Expression Regulation, Neoplastic - drug effects;Histone Deacetylase Inhibitors - pharmacology;Humans;Hypoglycemic Agents - pharmacology;Insulin;Insulin - pharmacology;Internal Medicine;Leptin receptor;Medical Education;Neoplasm Proteins - metabolism;Osmolar Concentration;Receptors, Leptin - metabolism;Thyroid Cancer, Papillary;Thyroid Neoplasms - genetics;Thyroid Neoplasms - metabolism;Up-Regulation - drug effects
Date:	2012-09-01
Issue Date:	2026-04-23 11:20:03 (UTC+8)
Publisher:	France: Elsevier SAS
Abstract:	摘要： Epidemiological studies suggest an important link between obesity and thyroid cancer. The adipose tissue-derived polypeptide leptin acting via leptin receptor may modulate cell migration of thyroid cancer cells. Previously we have demonstrated that leptin receptor is overexpressed in papillary thyroid cancer and is associated with tumor aggressiveness. The present study was undertaken to explore the possible regulatory factors which would influence leptin receptor expression in papillary thyroid cancer cells. We found that DNA methyltransferase inhibitor (5-Aza-2′-deoxycytidine) and histone deacetylase inhibitor (trichostatin A) reduced leptin receptor expression. Conversely, insulin upregulated leptin receptor expression in a time- and dose-dependent manner. Hypoxia-mimicking agent (cobalt chloride) had no effect on leptin receptor expression. Taken together, our study provides evidence that epigenetic events and insulin stimulation take part in regulation of leptin receptor expression in papillary thyroid cancer cells. 其他題名： Biomed Pharmacother 出版者： France: Elsevier SAS 出版日期： 2012-09-01 出處： Biomedicine & pharmacotherapy, 2012-09, Vol.66 (6), p.469-473 資源來源： Alma/SFX Local Collection 版權： 2012 Elsevier Masson SAS 版權： Elsevier Masson SAS 版權： Copyright © 2012 Elsevier Masson SAS. All rights reserved. 識別號： ISSN: 0753-3322 識別號： ISSN: 1950-6007 識別號： EISSN: 1950-6007 識別號： DOI: 10.1016/j.biopha.2012.03.008 識別號： PMID: 22560341
Appears in Collections:	[Department of Biomedical Sciences and Engineering ] journal & Dissertation

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