Reversible heart rhythm complexity impairment in patients with primary aldosteronism

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Title:	Reversible heart rhythm complexity impairment in patients with primary aldosteronism
Authors:	林澂;Lin, Yen-Hung;Wu, Vin-Cent;Lo, Men-Tzung;Wu, Xue-Ming;Hung, Chi-Sheng;Wu, Kwan-Dun;Lin, Chen;Ho, Yi-Lwun;Stowasser, Michael;Peng, Chung-Kang
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	639/705/1046;692/163/2743/1279;692/308/1892;Adenoma;Adrenalectomy;Aldosterone;Aldosterone - metabolism;Arrhythmias, Cardiac - etiology;Arrhythmias, Cardiac - physiopathology;Biological Clocks;Cardiac arrhythmia;Cardiovascular system;Computer Simulation;Data processing;Defibrillators;Electrocardiography, Ambulatory - methods;Endocrine disorders;Entropy;Female;Heart Rate;Humanities and Social Sciences;Humans;Hyperaldosteronism - complications;Hyperaldosteronism - physiopathology;Hypertension;Male;Middle Aged;Models, Cardiovascular;multidisciplinary;Renin;Science;Secretion
Date:	2015-08-18
Issue Date:	2026-04-23 11:20:13 (UTC+8)
Publisher:	Nature Publishing Group;London: Nature Publishing Group UK
Abstract:	摘要： Excess aldosterone secretion in patients with primary aldosteronism (PA) impairs their cardiovascular system. Heart rhythm complexity analysis, derived from heart rate variability (HRV), is a powerful tool to quantify the complex regulatory dynamics of human physiology. We prospectively analyzed 20 patients with aldosterone producing adenoma (APA) that underwent adrenalectomy and 25 patients with essential hypertension (EH). The heart rate data were analyzed by conventional HRV and heart rhythm complexity analysis including detrended fluctuation analysis (DFA) and multiscale entropy (MSE). We found APA patients had significantly decreased DFAα2 on DFA analysis and decreased area 1–5, area 6–15 and area 6–20 on MSE analysis (all p < 0.05). Area 1–5, area 6–15, area 6–20 in the MSE study correlated significantly with log-transformed renin activity and log-transformed aldosterone-renin ratio (all p < = 0.01). The conventional HRV parameters were comparable between PA and EH patients. After adrenalectomy, all the altered DFA and MSE parameters improved significantly (all p < 0.05). The conventional HRV parameters did not change. Our result suggested that heart rhythm complexity is impaired in APA patients and this is at least partially reversed by adrenalectomy. 其他題名： Sci Rep 出版者： London: Nature Publishing Group UK 出版日期： 2015-08-18 出處： Scientific reports, 2015-08, Vol.5 (1), p.11249, Article 11249 資源來源： Publicly Available Content Database 版權： The Author(s) 2015 版權： Copyright Nature Publishing Group Aug 2015 版權： Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited 識別號： ISSN: 2045-2322 識別號： EISSN: 2045-2322 識別號： DOI: 10.1038/srep11249 識別號： PMID: 26282603
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