Role of leukemia inhibitory factor in nasopharyngeal carcinogenesis

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Title:	Role of leukemia inhibitory factor in nasopharyngeal carcinogenesis
Authors:	劉淑貞;Liu, Shu-Chen;Chang, Yu-Sun
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Epstein-Barr virus;leukemia inhibitory factor;mTOR;nasopharyngeal carcinoma;p70S6K;radioresistance;Review
Date:	2014-01-01
Issue Date:	2026-04-23 11:20:20 (UTC+8)
Publisher:	Taylor and Francis Ltd.;United States: Taylor & Francis
Abstract:	摘要： Although Epstein-Barr virus-associated nasopharyngeal carcinoma (NPC) is a highly radiosensitive cancer, approximately 20% of patients with NPC develop local recurrence after radiation therapy. Multiple proinflammatory cytokines are thought to protect NPC tumor cells from immune surveillance and therapeutic interventions. The cytokine leukemia inhibitory factor (LIF) is a critical component of the NPC microenvironment. LIF influences tumor growth and survival, and is therefore considered a potential therapeutic target and/or prognostic predictor for NPC. High LIF levels have been detected in the circulating blood of patients with recurrent NPC and NPC tumor cells. This review discusses the molecular mechanisms that link LIF to NPC tumor progression and radioresistance. 其他題名： Mol Cell Oncol 出版者： United States: Taylor & Francis 出版日期： 2014-01-01 出處： Molecular & cellular oncology, 2014-01, Vol.1 (1), p.e29900 資源來源： Taylor & Francis Open Access (WRLC) 版權： Copyright © 2014 Landes Bioscience 2014 版權： Copyright © 2014 Landes Bioscience 2014 Landes Bioscience 識別號： ISSN: 2372-3556 識別號： ISSN: 2372-3548 識別號： EISSN: 2372-3556 識別號： DOI: 10.4161/mco.29900 識別號： PMID: 27308310
Appears in Collections:	[Department of Biomedical Sciences and Engineering ] journal & Dissertation

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