Simulated shift work in rats perturbs multiscale regulation of locomotor activity

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Title:	Simulated shift work in rats perturbs multiscale regulation of locomotor activity
Authors:	羅孟宗;Hsieh, Wan-Hsin;Escobar, Carolina;Yugay, Tatiana;Lo, Men-Tzung;Pittman-Polletta, Benjamin;Salgado-Delgado, Roberto;Scheer, Frank A. J. L.;Shea, Steven A.;Buijs, Ruud M.;Hu, Kun
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	Animals;Circadian Misalignment;Circadian Rhythm - physiology;Motor Activity;Multiscale Regulation;Photoperiod;Rats;Rats, Wistar;Shift Work;Suprachiasmatic Nucleus - physiology;Work Schedule Tolerance - physiology
Date:	2014-07-06
Issue Date:	2026-04-23 11:21:11 (UTC+8)
Publisher:	The Royal Society;England: The Royal Society
Abstract:	摘要： Motor activity possesses a multiscale regulation that is characterized by fractal activity fluctuations with similar structure across a wide range of timescales spanning minutes to hours. Fractal activity patterns are disturbed in animals after ablating the master circadian pacemaker (suprachiasmatic nucleus, SCN) and in humans with SCN dysfunction as occurs with aging and in dementia, suggesting the crucial role of the circadian system in the multiscale activity regulation. We hypothesized that the normal synchronization between behavioural cycles and the SCN-generated circadian rhythms is required for multiscale activity regulation. To test the hypothesis, we studied activity fluctuations of rats in a simulated shift work protocol that was designed to force animals to be active during the habitual resting phase of the circadian/daily cycle. We found that these animals had gradually decreased mean activity level and reduced 24-h activity rhythm amplitude, indicating disturbed circadian and behavioural cycles. Moreover, these animals had disrupted fractal activity patterns as characterized by more random activity fluctuations at multiple timescales from 4 to 12 h. Intriguingly, these activity disturbances exacerbated when the shift work schedule lasted longer and persisted even in the normal days (without forced activity) following the shift work. The disrupted circadian and fractal patterns resemble those of SCN-lesioned animals and of human patients with dementia, suggesting a detrimental impact of shift work on multiscale activity regulation. 其他題名： J. R. Soc. Interface 出版者： England: The Royal Society 出版日期： 2014-07-06 出處： Journal of the Royal Society interface, 2014-07, Vol.11 (96), p.20140318 版權： 2014 The Author(s) Published by the Royal Society. All rights reserved. 版權： 2014 The Author(s) Published by the Royal Society. All rights reserved. 2014 識別號： ISSN: 1742-5689 識別號： ISSN: 1742-5662 識別號： EISSN: 1742-5662 識別號： DOI: 10.1098/rsif.2014.0318 識別號： PMID: 24829282
Appears in Collections:	[Department of Biomedical Sciences and Engineering ] journal & Dissertation

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