Slug is temporally regulated by cyclin e in cell cycle and controls genome stability

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Title:	Slug is temporally regulated by cyclin e in cell cycle and controls genome stability
Authors:	許藝瓊;Wang, W-L;Huang, H-C;Kao, S-H;Hsu, Y-C;Wang, Y-T;Li, K-C;Chen, Y-J;Yu, S-L;Wang, S-P;Hsiao, T-H;Yang, P-C;Hong, T-M
Contributors:	生醫理工學院生醫科學與工程學系
Keywords:	631/67;631/80/84/2176;631/80/86;Apoptosis;Cancer;Cancer therapies;Cell Biology;Cell Cycle;Cell growth;Cell Line, Tumor;Cell Proliferation;Cyclin E;Cyclin E - metabolism;Cyclin-dependent kinase;Cyclin-dependent kinase 2;Cyclin-Dependent Kinase 2 - metabolism;Cyclin-dependent kinases;Deoxyribonucleic acid;DNA;DNA biosynthesis;DNA ligase (ATP);Epithelial-Mesenchymal Transition;Gene Expression Regulation, Neoplastic;Genetic aspects;Genetic regulation;Genetic research;Genomes;Genomic Instability;HEK293 Cells;HeLa Cells;Human Genetics;Humans;Internal Medicine;Kinases;Leupeptins - pharmacology;Medicine;Medicine & Public Health;Mesenchyme;Metastases;Metastasis;Neoplasms - genetics;Neoplasms - metabolism;Neoplasms - pathology;Oncology;Oncology, Experimental;original-article;Phosphorylation;Snail Family Transcription Factors;Transcription;Transcription factors;Transcription Factors - metabolism;Ubiquitin;Ubiquitin-proteasome system;Ubiquitination
Date:	2015-02-26
Issue Date:	2026-04-23 11:21:22 (UTC+8)
Publisher:	Nature Publishing Group;London: Springer Science and Business Media LLC
Abstract:	摘要： The transcriptional repressor Slug is best known to control epithelial–mesenchymal transition (EMT) and promote cancer invasion/metastasis. In this study, we demonstrate that Slug is temporally regulated during cell cycle progression. At G1/S transition, cyclin E–cyclin-dependent kinase 2 mediates the phosphorylation of Slug at Ser-54 and Ser-104, resulting in its ubiquitylation and degradation. Non-phosphorylatable Slug is markedly stabilized at G1/S transition compared with wild-type Slug and greatly leads to downregulation of DNA synthesis and checkpoint-related proteins, including TOP1, DNA Ligase IV and Rad17, reduces cell proliferation, delays S-phase progression and contributes to genome instability. Our results indicate that Slug has multifaceted roles in cancer progression by controlling both EMT and genome stability. 其他題名： Oncogene 出版者： London: Springer Science and Business Media LLC 出版日期： 2015-02-26 出處： Oncogene, 2015-02, Vol.34 (9), p.1116-1125 資源來源： EBSCO Academic Search Premier Database 版權： Macmillan Publishers Limited 2015 版權： COPYRIGHT 2015 Nature Publishing Group 版權： Copyright Nature Publishing Group Feb 26, 2015 版權： Macmillan Publishers Limited 2015. 識別號： ISSN: 0950-9232 識別號： ISSN: 1476-5594 識別號： EISSN: 1476-5594 識別號： DOI: 10.1038/onc.2014.58 識別號： PMID: 24662826 識別號： CODEN: ONCNES
Appears in Collections:	[Department of Biomedical Sciences and Engineering ] journal & Dissertation

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