SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma

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題名:	SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma
作者:	許藝瓊;Hsiao, Yi-Jing;Su, Kang-Yi;Hsu, Yi-Chiung;Chang, Gee-Chen;Chen, Jin-Shing;Chen, Hsuan-Yu;Hong, Qi-Sheng;Hsu, Shih-Chun;Kang, Po-Hsiang;Hsu, Chia-Ying;Ho, Bing-Ching;Yang, Tsung-Hui;Wang, Chia-Yu;Jou, Yuh-Shan;Yang, Pan-Chyr;Yu, Sung-Liang
貢獻者:	生醫理工學院生醫科學與工程學系
關鍵詞:	Adenocarcinoma - genetics;Adenocarcinoma - metabolism;Adenocarcinoma - pathology;Adenocarcinoma of Lung;Animals;Cell Line, Tumor;Epithelial-Mesenchymal Transition;Heterografts;Humans;Lung Neoplasms - genetics;Lung Neoplasms - metabolism;Lung Neoplasms - pathology;Mice;Mice, SCID;Nuclear Proteins - genetics;Nuclear Proteins - metabolism;Proto-Oncogene Proteins c-jun - antagonists & inhibitors;Proto-Oncogene Proteins c-jun - metabolism;Research Paper;Signal Transduction;Snail Family Transcription Factors - antagonists & inhibitors;Snail Family Transcription Factors - metabolism;Transfection;Up-Regulation
日期:	2016-01-01
上傳時間:	2026-04-23 11:21:25 (UTC+8)
出版者:	United States: Impact Journals LLC
摘要:	摘要： SPANXA (Sperm Protein Associated with the Nucleus on the X-chromosome, family members A1/A2) acts as a cancer-testis antigen expressed in normal testes, but dysregulated in various tumors. We found that SPANXA is highly expressed in low-invasive CL1-0 cells compared with isogenous high-invasive CL1-5 cells. SPANXA was preferably expressed in tumor tissues and associated with the prolonged survival of lung adenocarcinomas. SPANXA suppressed the invasion and metastasis of lung cancer cells in vitro and in vivo. By the expression microarray and pathway analysis, we found that the SPANXA-altered genes were enriched in the epithelial-mesenchymal transition (EMT) pathway. SPANXA reduced SNAI2 expression resulted in up-regulating E-cadherin. c-JUN acts as the positive-regulator of EMT. Silencing SPANXA increased c-JUN mRNA expression and blockage of c-JUN led to SNAI2 down-regulation. Our results clearly characterized SPANXA as an EMT inhibitor by suppressing c-JUN-SNAI2 axis in lung adenocarcinoma. 其他題名： Oncotarget 出版者： United States: Impact Journals LLC 出版日期： 2016-07-12 出處： Oncotarget, 2016-07, Vol.7 (28), p.44417-44429 版權： Copyright: © 2016 Hsiao et al. 2016 識別號： ISSN: 1949-2553 識別號： EISSN: 1949-2553 識別號： DOI: 10.18632/oncotarget.10088 識別號： PMID: 27323831
顯示於類別:	[生醫科學與工程學系] 期刊論文

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