Corneal neovascularization and contemporary antiangiogenic therapeutics

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題名:	Corneal neovascularization and contemporary antiangiogenic therapeutics
作者:	陳思妤;Hsu, Chih-Chien;Chang, Hua-Ming;Lin, Tai-Chi;Hung, Kuo-Hsuan;Chien, Ke-Hung;Chen, Szu-Yu;Chen, San-Ni;Chen, Yan-Ting
貢獻者:	理學院光電科學與工程學系
關鍵詞:	angiogenesis;Angiogenesis Inhibitors - therapeutic use;Animals;antiangiogenesis;corneal neovascularization;Corneal Neovascularization - drug therapy;Disease Models, Animal;Humans;immunosuppressant;Immunosuppressive Agents - therapeutic use;Internal Medicine;Platelet-Derived Growth Factor - physiology;Receptors, Vascular Endothelial Growth Factor - physiology;vascular endothelial growth factor;Vascular Endothelial Growth Factor A - antagonists & inhibitors;Vascular Endothelial Growth Factor A - physiology
日期:	2015-06-01
上傳時間:	2026-04-23 11:25:21 (UTC+8)
出版者:	Elsevier Taiwan LLC;Netherlands: Elsevier Taiwan
摘要:	摘要： Corneal neovascularization (NV), the excessive ingrowth of blood vessels from conjunctiva into the cornea, is a common sequela of disease insult that can lead to visual impairment. Clinically, topical steroid, argon laser photocoagulation, and subconjunctival injection of bevacizumab have been used to treat corneal NV. Sometimes, the therapies are ineffective, especially when the vessels are large. Large vessels are difficult to occlude and easily recanalized. Scientists and physicians are now dedicated to overcoming this problem. In this article, we briefly introduce the pathogenesis of corneal NV, and then highlight the existing animal models used in corneal NV research—the alkali-induced model and the suture-induced model. Most of all, we review the potential therapeutic targets (i.e., vascular endothelial growth factor and platelet-derived growth factor) and their corresponding inhibitors, as well as the immunosuppressants that have been discovered in recent years by corneal NV studies. 其他題名： J Chin Med Assoc 出版者： Netherlands: Elsevier Taiwan 出版日期： 2015-06-01 出處： Journal of the Chinese Medical Association, 2015-06, Vol.78 (6), p.323-330 資源來源： Elsevier ScienceDirect Journals Complete 版權： 2015 版權： Copyright © 2015. Published by Elsevier Taiwan. 識別號： ISSN: 1726-4901 識別號： ISSN: 1728-7731 識別號： EISSN: 1728-7731 識別號： DOI: 10.1016/j.jcma.2014.10.002 識別號： PMID: 25687646
顯示於類別:	[光電科學與工程學系] 期刊論文

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