Determination of chronological aging parameters in epidermal keratinocytes by in vivo harmonic generation microscopy

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题名:	Determination of chronological aging parameters in epidermal keratinocytes by in vivo harmonic generation microscopy
作者:	陳思妤;Liao, Yi-Hua;Chen, Szu-Yu;Chou, Sin-Yo;Wang, Pei-Hsun;Tsai, Ming-Rung;Sun, Chi-Kuang
贡献者:	理學院光電科學與工程學系
关键词:	Dermatological Applications
日期:	2013-01-01
上传时间:	2026-04-23 11:26:19 (UTC+8)
出版者:	The Optical Society;United States: Optical Society of America
摘要:	摘要： Skin aging is an important issue in geriatric and cosmetic dermatology. To quantitatively analyze changes in keratinocytes related to intrinsic aging, we exploited a 1230 nm-based in vivo harmonic generation microscopy, combining second- and third-harmonic generation modalities. 52 individuals (21 men and 31 women, age range 19-79) were examined on the sun-protected volar forearm. Through quantitative analysis by the standard algorithm provided, we found that the cellular and nuclear size of basal keratinocytes, but not that of granular cells, was significantly increased with advancing age. The cellular and nuclear areas, which have an increase of 0.51 μm(2) and 0.15 μm(2) per year, respectively, can serve as scoring indices for intrinsic skin aging. 其他題名： Biomed Opt Express 出版者： United States: Optical Society of America 出版日期： 2013-01-01 出處： Biomedical optics express, 2013-01, Vol.4 (1), p.77-88 資源來源： Optica Publishing Group Journals 版權： 2012 Optical Society of America 2012 OSA 識別號： ISSN: 2156-7085 識別號： EISSN: 2156-7085 識別號： DOI: 10.1364/BOE.4.000077 識別號： PMID: 23304649
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