A biomimetic tongue by photoluminescent metal-organic frameworks

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Title:	A biomimetic tongue by photoluminescent metal-organic frameworks
Authors:	李勝偉;Lee, Tu;Lin Lee, Hung;Hsun Tsai, Meng;Cheng, Shao-Liang;Lee, Sheng-Wei;Hu, Jung-Chih;Chen, Lien-Tai
Contributors:	工學院材料科學與工程研究所
Keywords:	acrylic acid;Animals;aqueous solutions;Biological and medical sciences;Biomimetic tongue;biomimetics;Biomimetics - instrumentation;Biosensing Techniques - instrumentation;biosensors;Biotechnology;caffeine;chelation;citric acid;emissions factor;Equipment Design;Equipment Failure Analysis;Food Analysis - instrumentation;Fundamental and applied biological sciences. Psychology;Humans;hydrogen bonding;Luminescent Measurements - instrumentation;Metal–organic frameworks;monosodium glutamate;Photoluminescence;principal component analysis;sodium chloride;sucrose;Taste;taste receptors;Tongue;umami;water;τ Scale
Date:	2013-05-05
Issue Date:	2026-04-23 11:27:31 (UTC+8)
Publisher:	Elsevier Ltd.;Kidlington: Elsevier B.V
Abstract:	摘要： The taste sensing capabilities of a “biomimetic tongue” based on the photoluminescence (PL) responses of metal–organic frameworks (MOFs), [In(OH)(bdc)]n (bdc=1,4-benzenedicarboxylate), [Tb(btc)]n (MOF-76, btc=benzene-1,3,5-tricarboxylate), and [Ca3(btc)2(DMF)2(H2O)2]·3H2O are proven on aqueous solutions of five basic tastants: sucrose (sweet), caffeine (bitter), citric acid (sour), sodium chloride (salty) and monosodium glutamate (umami). For [In(OH)(bdc)]n, the tastant interacts stereochemically with poly(acrylic acid) (PAA) and alters its conformations. The frequency and magnitude of chelation between COO− pendant groups of PAA and In3+ nodes of [In(OH)(bdc)]n framework influence the corresponding PL reponses. For MOF-76, the tastant interacts with incorporated water in MOF-76 through hydrogen bonding. The limitation of O–H bond stretching of water results in the enhancement of the PL intensity. For [Ca3(BTC)2(DMF)2(H2O)2]·3H2O, it is added as a third MOF component to increase the precision on taste discrimination. The significance of MOF-based “biomimetic tongue” includes: (1) PAA on [In(OH)(bdc)]n mimics the taste receptor cells (TRCs) for their structural flexibility, (2) the Weber-Fechner law of human sensing that sensation is proportional to the logarithm of the stimulus intensity is observed between the PL emission response of MOF-76 and the concentration of tastant, (3) the strength of taste is quantified by the τ scale and the PL emission intensity of MOF-76, which are dependent on the logarithmic tastant concentration, (4) the tastant is identified by the shape of the 3D principal component analysis contour map (i.e., pattern recognition method), and (5) the fabrication of [In(OH)(bdc)]n/PAA film by brushing is illustrated. ► We are the first group to perform taste-sensing using a poly(acrylic) acid (PAA)-chelated MOF. ► We are the first group to use anion sensing MOF-76 to measure the concentrations of sucrose, caffeine, citric acid, sodium chloride and monosodium glutamate. ► The PL intensity is related to the Tau scale in the strength of taste. ► We use the principal component analysis method to identify taste. ► MOF/PAA polymer composite thin film is developed. 其他題名： Biosens Bioelectron 出版者： Kidlington: Elsevier B.V 出版日期： 2013-05-15 出處： Biosensors & bioelectronics, 2013-05, Vol.43, p.56-62 版權： 2012 Elsevier B.V. 版權： 2014 INIST-CNRS 版權： Copyright © 2012 Elsevier B.V. All rights reserved. 識別號： ISSN: 0956-5663 識別號： ISSN: 1873-4235 識別號： EISSN: 1873-4235 識別號： DOI: 10.1016/j.bios.2012.11.014 識別號： PMID: 23277340
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