Both Enhanced Biocompatibility and Antibacterial Activity in Ag-Decorated TiO2 Nanotubes

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Title:	Both Enhanced Biocompatibility and Antibacterial Activity in Ag-Decorated TiO2 Nanotubes
Authors:	李勝偉;Lan, Ming-Ying;Liu, Chia-Pei;Huang, Her-Hsiung;Lee, Sheng-Wei
Contributors:	工學院材料科學與工程研究所
Keywords:	Anti-Bacterial Agents - chemistry;Anti-Bacterial Agents - pharmacology;Antibacterial activity;Antimicrobial agents;Bacteria;Biocompatibility;Biological activity;Biomedical materials;Cell Adhesion - drug effects;Cell Line;Cell Proliferation - drug effects;Cytotoxicity;Decoration;Electrolytes;Electron beams;Fibroblasts;Humans;Irradiation;Kinases;Light irradiation;Materials science;Microscopy, Electron, Scanning;Nanotechnology;Nanotubes;Nanotubes - chemistry;Nanotubes - ultrastructure;Silver;Silver - chemistry;Staphylococcus aureus;Staphylococcus aureus - drug effects;Stem cells;Studies;Titanium - chemistry;Titanium dioxide;Topography;Transplants & implants;U.V. radiation;Ultraviolet radiation;Wettability
Date:	2013-10-04
Issue Date:	2026-04-23 11:29:14 (UTC+8)
Publisher:	Public Library of Science;United States: Public Library of Science
Abstract:	摘要： In this study, Ag is electron-beam evaporated to modify the topography of anodic TiO2 nanotubes of different diameters to obtain an implant with enhanced antibacterial activity and biocompatibility. We found that highly hydrophilic as-grown TiO2 nanotubes became poorly hydrophilic with Ag incorporation; however they could effectively recover their wettability to some extent under ultraviolet light irradiation. The results obtained from antibacterial tests suggested that the Ag-decorated TiO2 nanotubes could greatly inhibit the growth of Staphylococcus aureus. In vitro biocompatibility evaluation indicated that fibroblast cells exhibited an obvious diameter-dependent behavior on both as-grown and Ag-decorated TiO2 nanotubes. Most importantly, of all samples, the smallest diameter (25-nm-diameter) Ag-decorated nanotubes exhibited the most obvious biological activity in promoting adhesion and proliferation of human fibroblasts, and this activity could be attributed to the highly irregular topography on a nanometric scale of the Ag-decorated nanotube surface. These experimental results demonstrate that by properly controlling the structural parameters of Ag-decorated TiO2 nanotubes, an implant surface can be produced that enhances biocompatibility and simultaneously boosts antibacterial activity. 其他題名： PLoS One 出版者： United States: Public Library of Science 出版日期： 2013-10-04 出處： PloS one, 2013-10, Vol.8 (10), p.e75364 資源來源： Agricultural & Environmental Science Collection 版權： 2013 Lan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 版權： 2013 Lan et al 2013 Lan et al 識別號： ISSN: 1932-6203 識別號： EISSN: 1932-6203 識別號： DOI: 10.1371/journal.pone.0075364 識別號： PMID: 24124484
Appears in Collections:	[Institute of Materials Science and Engineering] journal & Dissertation

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