Diameter selective behavior of human nasal epithelial cell on Ag-coated TiO2 nanotubes

NCUIR > Engineering College > Institute of Materials Science and Engineering > journal & Dissertation > Item 987654321/103462

Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/103462

Title:	Diameter selective behavior of human nasal epithelial cell on Ag-coated TiO2 nanotubes
Authors:	李勝隆;Lan, Ming-Ying;Lee, Sheng-Long;Huang, Her-Hsiung;Chen, Po-Fan;Liu, Chia-Pei;Lee, Sheng-Wei
Contributors:	工學院材料科學與工程研究所
Keywords:	Antibacterial;Biocompatibility;Human nasal epithelial cells;Pseudomonas aeruginosa;TiO2 nanotubes
Date:	2014-04-01
Issue Date:	2026-04-23 11:30:58 (UTC+8)
Publisher:	Elsevier Ltd.;Elsevier Ltd
Abstract:	摘要： Titanium oxide (TiO2), a light, strong, corrosion resistant, biocompatible and non-toxic metal, is widely used as dental or orthopedic implants, but is rarely used in nasal applications. There are three potential clinical applications for titanium in nasal surgery, including nasal septal perforation repairment, nasal reconstruction or rhinoplasty, and cerebral spinal fluid (CSF) rhinorrhea repairment. Nasal cavity is a contaminated cavity, thus to develop a nasal implant with antibacterial activity has its importance. We have developed self-organized TiO2 nanotubes with different diameters by utilizing an electrochemical anodization method and further decorated the TiO2 nanotubes with silver (Ag) layer by electron-beam deposition. The human nasal epithelial cells (HNEpCs) was used for evaluating the cytocompatibility of TiO2 nanotubes with or without Ag decoration, including cell adhesion, cell proliferation assay for analyzing cell growth condition, and scanning electronic microscopy (SEM) for observing cell morphology. Furthermore, Pseudomonus aeruginosa was used for assessing the antibacterial activity of titanium implants. Our results showed that 25-nm-diameter Ag-coated TiO2 nanotubes possess both good cytocompatibility with cultured HNEpCs and antibacterial activity against P. aeruginosa, as compared to 100-nm-diameter nanotubes. In conclusion, the small-diameter Ag-decorated TiO2 nanotubes have high biocompatibility and good antibacterial activity, and there is potential of its usage for future clinical applications as novel nasal implants. 出版者： Elsevier Ltd 出版日期： 2014-04-01 出處： Ceramics international, 2014-04, Vol.40 (3), p.4745-4751 版權： 2013 Elsevier Ltd and Techna Group S.r.l. 識別號： ISSN: 0272-8842 識別號： EISSN: 1873-3956 識別號： DOI: 10.1016/j.ceramint.2013.09.018
Appears in Collections:	[Institute of Materials Science and Engineering] journal & Dissertation

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