Fabrication and application of amperometric glucose biosensor based on a novel PtPd bimetallic nanoparticle decorated multi-walled carbon nanotube catalyst

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Title:	Fabrication and application of amperometric glucose biosensor based on a novel PtPd bimetallic nanoparticle decorated multi-walled carbon nanotube catalyst
Authors:	劉炯權;Chen, Kuan-Jung;Lee, Chia-Feng;Rick, John;Wang, Shih-Han;Liu, Chung-Chiun;Hwang, Bing-Joe
Contributors:	工學院材料科學與工程研究所
Keywords:	ascorbic acid;Biological and medical sciences;Biosensing Techniques - methods;Biosensors;Biotechnology;Blood Glucose - analysis;blood serum;carbon nanotubes;Catalysis;catalysts;coatings;detection limit;Electrochemical Techniques - methods;Electrodes;enzyme kinetics;fructose;Fundamental and applied biological sciences. Psychology;glassy carbon electrode;glucose;Glucose amperometric sensor;Humans;Hydrogen peroxide sensing;Metal Nanoparticles - chemistry;Methods. Procedures. Technologies;nanoparticles;Nanotubes, Carbon - chemistry;Palladium - chemistry;Platinum - chemistry;Pt-based bimetallic nanoparticles (NPs);PtPd NPs-decorated multi walled carbon nanotube catalyst;Reproducibility of Results;storage quality;transmission electron microscopy;uric acid;Various methods and equipments;X-ray diffraction
Date:	2012-03-15
Issue Date:	2026-04-23 11:34:34 (UTC+8)
Publisher:	Elsevier Ltd.;Kidlington: Elsevier B.V
Abstract:	摘要： ► Novel PtPd bimetallic nanoparticles decorated on multi-walled carbon nanotubes (PtPd-MWCNTs) catalyst was prepared by a modified Watanabe method. ► The resulting biosensor exhibited a good response to glucose with a wide linear range (0.062–14.07mM) and a low detection limit 0.031mM. ► The biosensor also showed a short response time (within 5s), and a high sensitivity (112μAmM−1cm−2). ► The biosensor exhibited high reproducibility, good storage stability and satisfactory anti-interference ability. A sensitive, selective and stable amperometric glucose biosensor employing novel PtPd bimetallic nanoparticles decorated on multi-walled carbon nanotubes (PtPd-MWCNTs) was investigated. PtPd-MWCNTs were prepared by a modified Watanabe method, and characterized by XRD and TEM. The biosensor was constructed by immobilizing the PtPd-MWCNTs catalysts in a Nafion film on a glassy carbon electrode. An inner Naﬁon film coating was used to eliminate common interferents such as uric acid, ascorbic acid and fructose. Finally, a highly porous surface with an orderly three-dimensional network enzyme layer (CS-GA-GOx) was fabricated by electrodeposition. The resulting biosensor exhibited a good response to glucose with a wide linear range (0.062–14.07mM) and a low detection limit 0.031mM. The biosensor also showed a short response time (within 5s), and a high sensitivity (112μAmM−1cm−2). The Michaelis–Menten constant (Km) was determined as 3.3mM. In addition, the biosensor exhibited high reproducibility, good storage stability and satisfactory anti-interference ability. The applicability of the biosensor to actual serum sample analysis was also evaluated. 其他題名： Biosens Bioelectron 出版者： Kidlington: Elsevier B.V 出版日期： 2012-03-15 出處： Biosensors & bioelectronics, 2012-03, Vol.33 (1), p.75-81 版權： 2011 Elsevier B.V. 版權： 2015 INIST-CNRS 版權： Copyright © 2011 Elsevier B.V. All rights reserved. 識別號： ISSN: 0956-5663 識別號： ISSN: 1873-4235 識別號： EISSN: 1873-4235 識別號： DOI: 10.1016/j.bios.2011.12.020 識別號： PMID: 22277115
Appears in Collections:	[Institute of Materials Science and Engineering] journal & Dissertation

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